Iron and microbial infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-12

AUTHORS

Ulrich E Schaible, Stefan H E Kaufmann

ABSTRACT

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. It is also a pivotal component of the innate immune response through its role in the generation of toxic oxygen and nitrogen intermediates. During evolution, the shared requirement of micro- and macroorganisms for this important nutrient has shaped the pathogen-host relationship. Here, we discuss how pathogens compete with the host for iron, and also how the host uses iron to counteract this threat. More... »

PAGES

946-953

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrmicro1046

DOI

http://dx.doi.org/10.1038/nrmicro1046

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033565781

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15550940


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