Genome-scale models of microbial cells: evaluating the consequences of constraints View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

Nathan D Price, Jennifer L Reed, Bernhard Ø Palsson

ABSTRACT

Microbial cells operate under governing constraints that limit their range of possible functions. With the availability of annotated genome sequences, it has become possible to reconstruct genome-scale biochemical reaction networks for microorganisms. The imposition of governing constraints on a reconstructed biochemical network leads to the definition of achievable cellular functions. In recent years, a substantial and growing toolbox of computational analysis methods has been developed to study the characteristics and capabilities of microorganisms using a constraint-based reconstruction and analysis (COBRA) approach. This approach provides a biochemically and genetically consistent framework for the generation of hypotheses and the testing of functions of microbial cells. More... »

PAGES

886-897

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  • Journal

    TITLE

    Nature Reviews Microbiology

    ISSUE

    11

    VOLUME

    2

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrmicro1023

    DOI

    http://dx.doi.org/10.1038/nrmicro1023

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046774154

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15494745


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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrmicro1023'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrmicro1023'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrmicro1023'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrmicro1023'


     

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