Antimicrobial reactive oxygen and nitrogen species: concepts and controversies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-10

AUTHORS

Ferric C Fang

ABSTRACT

Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host resistance to microbial pathogens. Decades of research have provided a detailed understanding of the regulation, generation and actions of these molecular mediators, as well as their roles in resisting infection. However, differences of opinion remain with regard to their host specificity, cell biology, sources and interactions with one another or with myeloperoxidase and granule proteases. More than a century after Metchnikoff first described phagocytosis, and more than four decades after the discovery of the burst of oxygen consumption that is associated with microbial killing, the seemingly elementary question of how phagocytes inhibit, kill and degrade microorganisms remains controversial. This review updates the reader on these concepts and the topical questions in the field. More... »

PAGES

820-832

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrmicro1004

    DOI

    http://dx.doi.org/10.1038/nrmicro1004

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000003896

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15378046


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    Download the RDF metadata as:  json-ld nt turtle xml License info

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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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