The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03-14

AUTHORS

Peter Spanogiannopoulos, Elizabeth N. Bess, Rachel N. Carmody, Peter J. Turnbaugh

ABSTRACT

Key PointsThe gut microbiome is a neglected component of the first-pass metabolism of xenobiotics before reaching the general circulation.Direct microbial metabolism of xenobiotics and their metabolites often involves reduction or hydrolysis, but most of the enzymes responsible for these reactions remain unknown.Microbial metabolism influences both efficacy and toxicity, producing bioactive compounds, inactive metabolites and toxins.Relevant host–microbial interactions include the expression of host genes that are involved in drug transport and metabolism, the interference with host enzymatic activity and the modulation of immune responses.The translational implications of these studies include the development of novel co-therapies and the identification of new biomarkers and drugs. More... »

PAGES

273-287

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    43 schema:description Key PointsThe gut microbiome is a neglected component of the first-pass metabolism of xenobiotics before reaching the general circulation.Direct microbial metabolism of xenobiotics and their metabolites often involves reduction or hydrolysis, but most of the enzymes responsible for these reactions remain unknown.Microbial metabolism influences both efficacy and toxicity, producing bioactive compounds, inactive metabolites and toxins.Relevant host–microbial interactions include the expression of host genes that are involved in drug transport and metabolism, the interference with host enzymatic activity and the modulation of immune responses.The translational implications of these studies include the development of novel co-therapies and the identification of new biomarkers and drugs.
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