The subcellular destinations of apc proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-05

AUTHORS

Mariann Bienz

ABSTRACT

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon, and is conserved in various organisms. Its best understood function is the destabilization of beta-catenin, a key effector of the Wnt signalling pathway. APC proteins are highly motile, and shuttle between several subcellular destinations. These destinations have prompted the discovery of new functions for the APC proteins, and this multitasking of APC might explain why its loss often leads to cancer. More... »

PAGES

328-338

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm806

    DOI

    http://dx.doi.org/10.1038/nrm806

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021935829

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11988767


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    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrm806'

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