Mechanisms and principles of homology search during recombination View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05-14

AUTHORS

Jörg Renkawitz, Claudio A. Lademann, Stefan Jentsch

ABSTRACT

Key PointsHomology search is the crucial step during homologous recombination that involves the encounter of two homologous sequences, the constant probing for homology and the final recognition of the homologous site.The mechanism of homology search, which was previously considered to be one of the most enigmatic processes in DNA double-strand break (DSB) repair, is now partially understood owing to several methodological advances.The proposed 'accelerated random search model' suggests that homology search functions by a random probing mechanism that is carried out by the RecA or RAD51 presynaptic nucleoprotein filament in three dimensions. However, the model further suggests that probing is accelerated by engaging multiple contacts of the filament with DNA and by sliding of the filament along DNA.As spatial proximity seems to be a key determinant of efficient homology search, chromatin architecture and nuclear organization have a decisive role during the search process.Mediators of homology search are either proteins or structures that restrict and guide the search to donor sequences, or factors that actively facilitate homology probing in the context of chromatin and histones. More... »

PAGES

369-383

References to SciGraph publications

  • 2007-04-08. Homology-driven chromatin remodeling by human RAD54 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-07-22. The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus in NATURE CELL BIOLOGY
  • 2012-12-18. Chromatin and the genome integrity network in NATURE REVIEWS GENETICS
  • 2012-02-07. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes in NATURE
  • 2013-05-09. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data in NATURE REVIEWS GENETICS
  • 2010-10-13. Genomics tools for unraveling chromosome architecture in NATURE BIOTECHNOLOGY
  • 2010-03. Maintaining genome stability at the replication fork in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-02-08. Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search in NATURE
  • 2008-05. Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures in NATURE
  • 2013-05-05. Effect of nuclear architecture on the efficiency of double-strand break repair in NATURE CELL BIOLOGY
  • 2013-12-22. RecA bundles mediate homology pairing between distant sisters during DNA break repair in NATURE
  • 2009-03-11. The emerging role of nuclear architecture in DNA repair and genome maintenance in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-06-28. DNA repair choice defines a common pathway for recruitment of chromatin regulators in NATURE COMMUNICATIONS
  • 2011-01-21. The MRE11 complex: starting from the ends in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-11-27. Advancing our understanding of functional genome organisation through studies in the fission yeast in CURRENT GENETICS
  • 2006-05. At the heart of the chromosome: SMC proteins in action in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-04-01. Chromosome territories, nuclear architecture and gene regulation in mammalian cells in NATURE REVIEWS GENETICS
  • 2012-04-08. Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery in NATURE CELL BIOLOGY
  • 2009-10. Recombinational DNA repair in a cellular context: a search for the homology search in NATURE REVIEWS MICROBIOLOGY
  • 1998-05. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins in NATURE
  • 2013-12-15. Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-01. Finding a match: how do homologous sequences get together for recombination? in NATURE REVIEWS GENETICS
  • 2007-05-23. Nuclear organization of the genome and the potential for gene regulation in NATURE
  • 2010-05-02. A three-dimensional model of the yeast genome in NATURE
  • 2013-02-12. Organization and segregation of bacterial chromosomes in NATURE REVIEWS GENETICS
  • 2003-02-10. Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51–ssDNA nucleoprotein filament in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-03-11. Recombination centres and the orchestration of V(D)J recombination in NATURE REVIEWS IMMUNOLOGY
  • 2006-08-06. Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination in NATURE CELL BIOLOGY
  • 2013-03-05. Functional implications of genome topology in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-07-23. Monitoring DNA Recombination Initiated by HO Endonuclease in DNA REPAIR PROTOCOLS
  • 2012-04-08. Increased chromosome mobility facilitates homology search during recombination in NATURE CELL BIOLOGY
  • 2008-11-02. High-resolution statistical mapping reveals gene territories in live yeast in NATURE METHODS
  • 2007-11-05. Gene regulation through nuclear organization in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-04-28. In Vitro Assays for DNA Pairing and Recombination-Associated DNA Synthesis in DNA RECOMBINATION
  • 2003-06-15. Spatial proximity of translocation-prone gene loci in human lymphomas in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm3805

    DOI

    http://dx.doi.org/10.1038/nrm3805

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032849534

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24824069


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomic Instability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombination, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria.", 
              "id": "http://www.grid.ac/institutes/grid.33565.36", 
              "name": [
                "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany", 
                "Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Renkawitz", 
            "givenName": "J\u00f6rg", 
            "id": "sg:person.01220754412.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220754412.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418615.f", 
              "name": [
                "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lademann", 
            "givenName": "Claudio A.", 
            "id": "sg:person.0731152132.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731152132.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418615.f", 
              "name": [
                "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jentsch", 
            "givenName": "Stefan", 
            "id": "sg:person.01133324361.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133324361.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrg3345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022165051", 
              "https://doi.org/10.1038/nrg3345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009545445", 
              "https://doi.org/10.1038/nsb901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013624554", 
              "https://doi.org/10.1038/nature10909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048335394", 
              "https://doi.org/10.1038/nsmb.2737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051441726", 
              "https://doi.org/10.1038/30037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007691150", 
              "https://doi.org/10.1038/ncb2472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-129-1_21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023043864", 
              "https://doi.org/10.1007/978-1-61779-129-1_21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019139948", 
              "https://doi.org/10.1038/nsmb1223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022335019", 
              "https://doi.org/10.1038/ncb1619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038110714", 
              "https://doi.org/10.1038/nrm2651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014676412", 
              "https://doi.org/10.1038/nature10782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011927401", 
              "https://doi.org/10.1038/nmeth.1266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014735134", 
              "https://doi.org/10.1038/nri2941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049015485", 
              "https://doi.org/10.1038/nrmicro2206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016407041", 
              "https://doi.org/10.1038/nsmb1324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046147193", 
              "https://doi.org/10.1038/nrg3454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35066075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000190833", 
              "https://doi.org/10.1038/35066075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006227264", 
              "https://doi.org/10.1038/nature06971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035724072", 
              "https://doi.org/10.1038/nrm2852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053023169", 
              "https://doi.org/10.1038/ng1177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016342364", 
              "https://doi.org/10.1038/nrg3375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002449610", 
              "https://doi.org/10.1038/nbt.1680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-998-3_25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043058976", 
              "https://doi.org/10.1007/978-1-61779-998-3_25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038369414", 
              "https://doi.org/10.1038/ncomms3084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038898150", 
              "https://doi.org/10.1038/ncb2745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048245629", 
              "https://doi.org/10.1038/nature12868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004826220", 
              "https://doi.org/10.1038/ncb1466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046380041", 
              "https://doi.org/10.1038/nsmb.2474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003874223", 
              "https://doi.org/10.1038/nrm1909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00294-010-0327-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042612139", 
              "https://doi.org/10.1007/s00294-010-0327-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035058324", 
              "https://doi.org/10.1038/nrm3047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003747523", 
              "https://doi.org/10.1038/nature05916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012207766", 
              "https://doi.org/10.1038/nature08973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020059474", 
              "https://doi.org/10.1038/nrg2224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047276321", 
              "https://doi.org/10.1038/ncb2465"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-05-14", 
        "datePublishedReg": "2014-05-14", 
        "description": "Key PointsHomology search is the crucial step during homologous recombination that involves the encounter of two homologous sequences, the constant probing for homology and the final recognition of the homologous site.The mechanism of homology search, which was previously considered to be one of the most enigmatic processes in DNA double-strand break (DSB) repair, is now partially understood owing to several methodological advances.The proposed 'accelerated random search model' suggests that homology search functions by a random probing mechanism that is carried out by the RecA or RAD51 presynaptic nucleoprotein filament in three dimensions. However, the model further suggests that probing is accelerated by engaging multiple contacts of the filament with DNA and by sliding of the filament along DNA.As spatial proximity seems to be a key determinant of efficient homology search, chromatin architecture and nuclear organization have a decisive role during the search process.Mediators of homology search are either proteins or structures that restrict and guide the search to donor sequences, or factors that actively facilitate homology probing in the context of chromatin and histones.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nrm3805", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1023609", 
            "issn": [
              "1471-0072", 
              "1471-0080"
            ], 
            "name": "Nature Reviews Molecular Cell Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "keywords": [
          "homology search", 
          "DNA double-strand break repair", 
          "double-strand break repair", 
          "context of chromatin", 
          "presynaptic nucleoprotein filament", 
          "chromatin architecture", 
          "nuclear organization", 
          "nucleoprotein filament", 
          "homologous recombination", 
          "break repair", 
          "homologous sequences", 
          "enigmatic process", 
          "homologous sites", 
          "homology", 
          "DNA", 
          "efficient homology search", 
          "filaments", 
          "recombination", 
          "sequence", 
          "key determinant", 
          "methodological advances", 
          "chromatin", 
          "RecA", 
          "spatial proximity", 
          "histones", 
          "crucial step", 
          "mechanism", 
          "protein", 
          "sites", 
          "multiple contacts", 
          "repair", 
          "role", 
          "random search model", 
          "search model", 
          "search function", 
          "function", 
          "decisive role", 
          "mediators", 
          "proximity", 
          "determinants", 
          "process", 
          "advances", 
          "search process", 
          "structure", 
          "factors", 
          "step", 
          "search", 
          "recognition", 
          "organization", 
          "model", 
          "contact", 
          "architecture", 
          "owing", 
          "final recognition", 
          "probing mechanism", 
          "dimensions", 
          "context", 
          "principles", 
          "encounters"
        ], 
        "name": "Mechanisms and principles of homology search during recombination", 
        "pagination": "369-383", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032849534"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrm3805"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24824069"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrm3805", 
          "https://app.dimensions.ai/details/publication/pub.1032849534"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_617.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nrm3805"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'


     

    This table displays all metadata directly associated to this object as RDF triples.

    306 TRIPLES      21 PREDICATES      126 URIs      83 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrm3805 schema:about N37a359ece21b4fc8b8ca5ce7e2965d57
    2 N5a92303b4c59486b822fec326f7d21af
    3 Na55aa353a11546b3a70f357600276046
    4 Nbc8e33eaee8c4afa8ac53898f8dec5b1
    5 Nc5d1ea0d3ceb42e5b894dff8a00aab58
    6 Ne8eb6ebf13b5419787eb05607587d7a8
    7 Nea4ace6dca9f49569ba4f8601ec1ed56
    8 anzsrc-for:06
    9 anzsrc-for:0601
    10 schema:author Nd00c7d9c91104e6c96e4270dacb87592
    11 schema:citation sg:pub.10.1007/978-1-61779-129-1_21
    12 sg:pub.10.1007/978-1-61779-998-3_25
    13 sg:pub.10.1007/s00294-010-0327-x
    14 sg:pub.10.1038/30037
    15 sg:pub.10.1038/35066075
    16 sg:pub.10.1038/nature05916
    17 sg:pub.10.1038/nature06971
    18 sg:pub.10.1038/nature08973
    19 sg:pub.10.1038/nature10782
    20 sg:pub.10.1038/nature10909
    21 sg:pub.10.1038/nature12868
    22 sg:pub.10.1038/nbt.1680
    23 sg:pub.10.1038/ncb1466
    24 sg:pub.10.1038/ncb1619
    25 sg:pub.10.1038/ncb2465
    26 sg:pub.10.1038/ncb2472
    27 sg:pub.10.1038/ncb2745
    28 sg:pub.10.1038/ncomms3084
    29 sg:pub.10.1038/ng1177
    30 sg:pub.10.1038/nmeth.1266
    31 sg:pub.10.1038/nrg2224
    32 sg:pub.10.1038/nrg3345
    33 sg:pub.10.1038/nrg3375
    34 sg:pub.10.1038/nrg3454
    35 sg:pub.10.1038/nri2941
    36 sg:pub.10.1038/nrm1909
    37 sg:pub.10.1038/nrm2651
    38 sg:pub.10.1038/nrm2852
    39 sg:pub.10.1038/nrm3047
    40 sg:pub.10.1038/nrmicro2206
    41 sg:pub.10.1038/nsb901
    42 sg:pub.10.1038/nsmb.2474
    43 sg:pub.10.1038/nsmb.2737
    44 sg:pub.10.1038/nsmb1223
    45 sg:pub.10.1038/nsmb1324
    46 schema:datePublished 2014-05-14
    47 schema:datePublishedReg 2014-05-14
    48 schema:description Key PointsHomology search is the crucial step during homologous recombination that involves the encounter of two homologous sequences, the constant probing for homology and the final recognition of the homologous site.The mechanism of homology search, which was previously considered to be one of the most enigmatic processes in DNA double-strand break (DSB) repair, is now partially understood owing to several methodological advances.The proposed 'accelerated random search model' suggests that homology search functions by a random probing mechanism that is carried out by the RecA or RAD51 presynaptic nucleoprotein filament in three dimensions. However, the model further suggests that probing is accelerated by engaging multiple contacts of the filament with DNA and by sliding of the filament along DNA.As spatial proximity seems to be a key determinant of efficient homology search, chromatin architecture and nuclear organization have a decisive role during the search process.Mediators of homology search are either proteins or structures that restrict and guide the search to donor sequences, or factors that actively facilitate homology probing in the context of chromatin and histones.
    49 schema:genre article
    50 schema:isAccessibleForFree false
    51 schema:isPartOf N4443b450b5d041fabbc5a93e51125b6f
    52 Ne719bda0c10745da86da2edb224beadf
    53 sg:journal.1023609
    54 schema:keywords DNA
    55 DNA double-strand break repair
    56 RecA
    57 advances
    58 architecture
    59 break repair
    60 chromatin
    61 chromatin architecture
    62 contact
    63 context
    64 context of chromatin
    65 crucial step
    66 decisive role
    67 determinants
    68 dimensions
    69 double-strand break repair
    70 efficient homology search
    71 encounters
    72 enigmatic process
    73 factors
    74 filaments
    75 final recognition
    76 function
    77 histones
    78 homologous recombination
    79 homologous sequences
    80 homologous sites
    81 homology
    82 homology search
    83 key determinant
    84 mechanism
    85 mediators
    86 methodological advances
    87 model
    88 multiple contacts
    89 nuclear organization
    90 nucleoprotein filament
    91 organization
    92 owing
    93 presynaptic nucleoprotein filament
    94 principles
    95 probing mechanism
    96 process
    97 protein
    98 proximity
    99 random search model
    100 recognition
    101 recombination
    102 repair
    103 role
    104 search
    105 search function
    106 search model
    107 search process
    108 sequence
    109 sites
    110 spatial proximity
    111 step
    112 structure
    113 schema:name Mechanisms and principles of homology search during recombination
    114 schema:pagination 369-383
    115 schema:productId N66f10335bd164ab7a099d51130bcd80e
    116 N8570275cf1364d92a9ab5c45ec7a5c68
    117 Nc212eac369064ac8a1c083786bf05666
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032849534
    119 https://doi.org/10.1038/nrm3805
    120 schema:sdDatePublished 2022-08-04T17:01
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher Nc6eb8cad584c40f2ab4f4934a4fd5b7d
    123 schema:url https://doi.org/10.1038/nrm3805
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N37a359ece21b4fc8b8ca5ce7e2965d57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Genomic Instability
    129 rdf:type schema:DefinedTerm
    130 N4443b450b5d041fabbc5a93e51125b6f schema:issueNumber 6
    131 rdf:type schema:PublicationIssue
    132 N5a92303b4c59486b822fec326f7d21af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Animals
    134 rdf:type schema:DefinedTerm
    135 N66f10335bd164ab7a099d51130bcd80e schema:name dimensions_id
    136 schema:value pub.1032849534
    137 rdf:type schema:PropertyValue
    138 N8570275cf1364d92a9ab5c45ec7a5c68 schema:name pubmed_id
    139 schema:value 24824069
    140 rdf:type schema:PropertyValue
    141 Na55aa353a11546b3a70f357600276046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Humans
    143 rdf:type schema:DefinedTerm
    144 Na7e25208d0f741bcb4c94b030c1aea05 rdf:first sg:person.0731152132.26
    145 rdf:rest Ne2ed3072348f4fa8bc1d417d8ab40daa
    146 Nbc8e33eaee8c4afa8ac53898f8dec5b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name DNA Repair
    148 rdf:type schema:DefinedTerm
    149 Nc212eac369064ac8a1c083786bf05666 schema:name doi
    150 schema:value 10.1038/nrm3805
    151 rdf:type schema:PropertyValue
    152 Nc5d1ea0d3ceb42e5b894dff8a00aab58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Recombination, Genetic
    154 rdf:type schema:DefinedTerm
    155 Nc6eb8cad584c40f2ab4f4934a4fd5b7d schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 Nd00c7d9c91104e6c96e4270dacb87592 rdf:first sg:person.01220754412.82
    158 rdf:rest Na7e25208d0f741bcb4c94b030c1aea05
    159 Ne2ed3072348f4fa8bc1d417d8ab40daa rdf:first sg:person.01133324361.32
    160 rdf:rest rdf:nil
    161 Ne719bda0c10745da86da2edb224beadf schema:volumeNumber 15
    162 rdf:type schema:PublicationVolume
    163 Ne8eb6ebf13b5419787eb05607587d7a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name DNA Damage
    165 rdf:type schema:DefinedTerm
    166 Nea4ace6dca9f49569ba4f8601ec1ed56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Chromosomes
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Biological Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Biochemistry and Cell Biology
    174 rdf:type schema:DefinedTerm
    175 sg:journal.1023609 schema:issn 1471-0072
    176 1471-0080
    177 schema:name Nature Reviews Molecular Cell Biology
    178 schema:publisher Springer Nature
    179 rdf:type schema:Periodical
    180 sg:person.01133324361.32 schema:affiliation grid-institutes:grid.418615.f
    181 schema:familyName Jentsch
    182 schema:givenName Stefan
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133324361.32
    184 rdf:type schema:Person
    185 sg:person.01220754412.82 schema:affiliation grid-institutes:grid.33565.36
    186 schema:familyName Renkawitz
    187 schema:givenName Jörg
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220754412.82
    189 rdf:type schema:Person
    190 sg:person.0731152132.26 schema:affiliation grid-institutes:grid.418615.f
    191 schema:familyName Lademann
    192 schema:givenName Claudio A.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731152132.26
    194 rdf:type schema:Person
    195 sg:pub.10.1007/978-1-61779-129-1_21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023043864
    196 https://doi.org/10.1007/978-1-61779-129-1_21
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/978-1-61779-998-3_25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043058976
    199 https://doi.org/10.1007/978-1-61779-998-3_25
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s00294-010-0327-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042612139
    202 https://doi.org/10.1007/s00294-010-0327-x
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/30037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051441726
    205 https://doi.org/10.1038/30037
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/35066075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000190833
    208 https://doi.org/10.1038/35066075
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature05916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003747523
    211 https://doi.org/10.1038/nature05916
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature06971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006227264
    214 https://doi.org/10.1038/nature06971
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature08973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012207766
    217 https://doi.org/10.1038/nature08973
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature10782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014676412
    220 https://doi.org/10.1038/nature10782
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nature10909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013624554
    223 https://doi.org/10.1038/nature10909
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nature12868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048245629
    226 https://doi.org/10.1038/nature12868
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nbt.1680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002449610
    229 https://doi.org/10.1038/nbt.1680
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/ncb1466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004826220
    232 https://doi.org/10.1038/ncb1466
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/ncb1619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022335019
    235 https://doi.org/10.1038/ncb1619
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/ncb2465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047276321
    238 https://doi.org/10.1038/ncb2465
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ncb2472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007691150
    241 https://doi.org/10.1038/ncb2472
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ncb2745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038898150
    244 https://doi.org/10.1038/ncb2745
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/ncomms3084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038369414
    247 https://doi.org/10.1038/ncomms3084
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/ng1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053023169
    250 https://doi.org/10.1038/ng1177
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nmeth.1266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011927401
    253 https://doi.org/10.1038/nmeth.1266
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nrg2224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020059474
    256 https://doi.org/10.1038/nrg2224
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nrg3345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022165051
    259 https://doi.org/10.1038/nrg3345
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nrg3375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016342364
    262 https://doi.org/10.1038/nrg3375
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nrg3454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046147193
    265 https://doi.org/10.1038/nrg3454
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nri2941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014735134
    268 https://doi.org/10.1038/nri2941
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nrm1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003874223
    271 https://doi.org/10.1038/nrm1909
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nrm2651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038110714
    274 https://doi.org/10.1038/nrm2651
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nrm2852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035724072
    277 https://doi.org/10.1038/nrm2852
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nrm3047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035058324
    280 https://doi.org/10.1038/nrm3047
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nrmicro2206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049015485
    283 https://doi.org/10.1038/nrmicro2206
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nsb901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009545445
    286 https://doi.org/10.1038/nsb901
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/nsmb.2474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046380041
    289 https://doi.org/10.1038/nsmb.2474
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nsmb.2737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048335394
    292 https://doi.org/10.1038/nsmb.2737
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nsmb1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019139948
    295 https://doi.org/10.1038/nsmb1223
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nsmb1324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016407041
    298 https://doi.org/10.1038/nsmb1324
    299 rdf:type schema:CreativeWork
    300 grid-institutes:grid.33565.36 schema:alternateName Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria.
    301 schema:name Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany
    302 Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria.
    303 rdf:type schema:Organization
    304 grid-institutes:grid.418615.f schema:alternateName Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany
    305 schema:name Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany
    306 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...