Ontology type: schema:ScholarlyArticle
2014-05-14
AUTHORSJörg Renkawitz, Claudio A. Lademann, Stefan Jentsch
ABSTRACTKey PointsHomology search is the crucial step during homologous recombination that involves the encounter of two homologous sequences, the constant probing for homology and the final recognition of the homologous site.The mechanism of homology search, which was previously considered to be one of the most enigmatic processes in DNA double-strand break (DSB) repair, is now partially understood owing to several methodological advances.The proposed 'accelerated random search model' suggests that homology search functions by a random probing mechanism that is carried out by the RecA or RAD51 presynaptic nucleoprotein filament in three dimensions. However, the model further suggests that probing is accelerated by engaging multiple contacts of the filament with DNA and by sliding of the filament along DNA.As spatial proximity seems to be a key determinant of efficient homology search, chromatin architecture and nuclear organization have a decisive role during the search process.Mediators of homology search are either proteins or structures that restrict and guide the search to donor sequences, or factors that actively facilitate homology probing in the context of chromatin and histones. More... »
PAGES369-383
http://scigraph.springernature.com/pub.10.1038/nrm3805
DOIhttp://dx.doi.org/10.1038/nrm3805
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1032849534
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24824069
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosomes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Damage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Repair",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genomic Instability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recombination, Genetic",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria.",
"id": "http://www.grid.ac/institutes/grid.33565.36",
"name": [
"Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany",
"Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria."
],
"type": "Organization"
},
"familyName": "Renkawitz",
"givenName": "J\u00f6rg",
"id": "sg:person.01220754412.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220754412.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany",
"id": "http://www.grid.ac/institutes/grid.418615.f",
"name": [
"Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany"
],
"type": "Organization"
},
"familyName": "Lademann",
"givenName": "Claudio A.",
"id": "sg:person.0731152132.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731152132.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany",
"id": "http://www.grid.ac/institutes/grid.418615.f",
"name": [
"Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany"
],
"type": "Organization"
},
"familyName": "Jentsch",
"givenName": "Stefan",
"id": "sg:person.01133324361.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133324361.32"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nrg3345",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022165051",
"https://doi.org/10.1038/nrg3345"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsb901",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009545445",
"https://doi.org/10.1038/nsb901"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013624554",
"https://doi.org/10.1038/nature10909"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.2737",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048335394",
"https://doi.org/10.1038/nsmb.2737"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/30037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051441726",
"https://doi.org/10.1038/30037"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2472",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007691150",
"https://doi.org/10.1038/ncb2472"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-61779-129-1_21",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023043864",
"https://doi.org/10.1007/978-1-61779-129-1_21"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb1223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019139948",
"https://doi.org/10.1038/nsmb1223"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1619",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022335019",
"https://doi.org/10.1038/ncb1619"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2651",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038110714",
"https://doi.org/10.1038/nrm2651"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10782",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014676412",
"https://doi.org/10.1038/nature10782"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1266",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011927401",
"https://doi.org/10.1038/nmeth.1266"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri2941",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014735134",
"https://doi.org/10.1038/nri2941"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro2206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049015485",
"https://doi.org/10.1038/nrmicro2206"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb1324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016407041",
"https://doi.org/10.1038/nsmb1324"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg3454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046147193",
"https://doi.org/10.1038/nrg3454"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35066075",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000190833",
"https://doi.org/10.1038/35066075"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06971",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006227264",
"https://doi.org/10.1038/nature06971"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm2852",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035724072",
"https://doi.org/10.1038/nrm2852"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053023169",
"https://doi.org/10.1038/ng1177"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg3375",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016342364",
"https://doi.org/10.1038/nrg3375"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.1680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002449610",
"https://doi.org/10.1038/nbt.1680"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-61779-998-3_25",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043058976",
"https://doi.org/10.1007/978-1-61779-998-3_25"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms3084",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038369414",
"https://doi.org/10.1038/ncomms3084"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038898150",
"https://doi.org/10.1038/ncb2745"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12868",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048245629",
"https://doi.org/10.1038/nature12868"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004826220",
"https://doi.org/10.1038/ncb1466"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.2474",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046380041",
"https://doi.org/10.1038/nsmb.2474"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm1909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003874223",
"https://doi.org/10.1038/nrm1909"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00294-010-0327-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042612139",
"https://doi.org/10.1007/s00294-010-0327-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm3047",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035058324",
"https://doi.org/10.1038/nrm3047"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05916",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003747523",
"https://doi.org/10.1038/nature05916"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08973",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012207766",
"https://doi.org/10.1038/nature08973"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2224",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020059474",
"https://doi.org/10.1038/nrg2224"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2465",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047276321",
"https://doi.org/10.1038/ncb2465"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-05-14",
"datePublishedReg": "2014-05-14",
"description": "Key PointsHomology search is the crucial step during homologous recombination that involves the encounter of two homologous sequences, the constant probing for homology and the final recognition of the homologous site.The mechanism of homology search, which was previously considered to be one of the most enigmatic processes in DNA double-strand break (DSB) repair, is now partially understood owing to several methodological advances.The proposed 'accelerated random search model' suggests that homology search functions by a random probing mechanism that is carried out by the RecA or RAD51 presynaptic nucleoprotein filament in three dimensions. However, the model further suggests that probing is accelerated by engaging multiple contacts of the filament with DNA and by sliding of the filament along DNA.As spatial proximity seems to be a key determinant of efficient homology search, chromatin architecture and nuclear organization have a decisive role during the search process.Mediators of homology search are either proteins or structures that restrict and guide the search to donor sequences, or factors that actively facilitate homology probing in the context of chromatin and histones.",
"genre": "article",
"id": "sg:pub.10.1038/nrm3805",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1023609",
"issn": [
"1471-0072",
"1471-0080"
],
"name": "Nature Reviews Molecular Cell Biology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "15"
}
],
"keywords": [
"homology search",
"DNA double-strand break repair",
"double-strand break repair",
"context of chromatin",
"presynaptic nucleoprotein filament",
"chromatin architecture",
"nuclear organization",
"nucleoprotein filament",
"homologous recombination",
"break repair",
"homologous sequences",
"enigmatic process",
"homologous sites",
"homology",
"DNA",
"efficient homology search",
"filaments",
"recombination",
"sequence",
"key determinant",
"methodological advances",
"chromatin",
"RecA",
"spatial proximity",
"histones",
"crucial step",
"mechanism",
"protein",
"sites",
"multiple contacts",
"repair",
"role",
"random search model",
"search model",
"search function",
"function",
"decisive role",
"mediators",
"proximity",
"determinants",
"process",
"advances",
"search process",
"structure",
"factors",
"step",
"search",
"recognition",
"organization",
"model",
"contact",
"architecture",
"owing",
"final recognition",
"probing mechanism",
"dimensions",
"context",
"principles",
"encounters"
],
"name": "Mechanisms and principles of homology search during recombination",
"pagination": "369-383",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1032849534"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nrm3805"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24824069"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nrm3805",
"https://app.dimensions.ai/details/publication/pub.1032849534"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:01",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_617.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nrm3805"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrm3805'
This table displays all metadata directly associated to this object as RDF triples.
306 TRIPLES
21 PREDICATES
126 URIs
83 LITERALS
14 BLANK NODES