Emerging roles for chromatin as a signal integration and storage platform View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

Aimee I. Badeaux, Yang Shi

ABSTRACT

Cells of a multicellular organism, all containing nearly identical genetic information, respond to differentiation cues in variable ways. In addition, cells are plastic, able to execute their specialized function while maintaining the ability to adapt to environmental changes. This is achieved through multiple mechanisms, including the direct regulation of chromatin-based processes in response to stimuli. How signal transduction pathways directly communicate with chromatin to change the epigenetic landscape is poorly understood. The preponderance of covalent modifications on histone tails coupled with a relatively small number of functional outputs raises the possibility that chromatin acts as a site of signal integration and storage. More... »

PAGES

211

References to SciGraph publications

  • 2012-03. Suppression of the antiviral response by an influenza histone mimic in NATURE
  • 2011-02. Feedback regulation of EGFR signalling: decision making by early and delayed loops in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-10. Identification of CDK2 substrates in human cell lysates in GENOME BIOLOGY
  • 2010-04. Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4 in NATURE
  • 2008-10-09. Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism in NATURE
  • 2009-02. ChIP-seq accurately predicts tissue-specific activity of enhancers in NATURE
  • 2012-04. Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms in JOURNAL OF NEURAL TRANSMISSION
  • 2009-11. Nutritional programming of the metabolic syndrome in NATURE REVIEWS ENDOCRINOLOGY
  • 2011-09. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a in NATURE COMMUNICATIONS
  • 2012-04-04. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations in NATURE
  • 2012-03. Chromatin replication and epigenome maintenance in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2011-04. Enhancer function: new insights into the regulation of tissue-specific gene expression in NATURE REVIEWS GENETICS
  • 2011-11. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans in NATURE
  • 2012-03. Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106 in NATURE
  • 2010-12. Suppression of inflammation by a synthetic histone mimic in NATURE
  • 2011-01. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling in NATURE IMMUNOLOGY
  • 2010-07. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression in NATURE
  • 2009-10-08. JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin in NATURE
  • 2012-08. Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-11. Regulation of p53 activity through lysine methylation in NATURE
  • 2011-01. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-12. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery in NATURE REVIEWS DRUG DISCOVERY
  • 2007-11. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-05. Histone methylation: a dynamic mark in health, disease and inheritance in NATURE REVIEWS GENETICS
  • 2010-09. Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint in NATURE
  • 2009-03. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2003-10. Binary switches and modification cassettes in histone biology and beyond in NATURE
  • 2007-10-18. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive in NATURE
  • 2008-10-09. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 in NATURE
  • 2012-09. PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2000-01. The language of covalent histone modifications in NATURE
  • 2010-11. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 in NATURE CELL BIOLOGY
  • 2011-03. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms in CELL RESEARCH
  • 2013-01. Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity in NEUROPSYCHOPHARMACOLOGY
  • 2009-05. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis in NATURE
  • 2011-01. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells in NATURE CELL BIOLOGY
  • 2012-03. IDH mutation impairs histone demethylation and results in a block to cell differentiation in NATURE
  • 2013-01. Epigenetic Mechanisms in Learned Fear: Implications for PTSD in NEUROPSYCHOPHARMACOLOGY
  • 2011-06. PKA-dependent regulation of the histone lysine demethylase complex PHF2–ARID5B in NATURE CELL BIOLOGY
  • 2011-12. GlcNAcylation of histone H2B facilitates its monoubiquitination in NATURE
  • 2008-10-09. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix in NATURE
  • 2010-12. Global turnover of histone post-translational modifications and variants in human cells in EPIGENETICS & CHROMATIN
  • 2007-09-06. p53 is regulated by the lysine demethylase LSD1 in NATURE
  • 2011-07. Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-07. Developmental reprogramming of cancer susceptibility in NATURE REVIEWS CANCER
  • 2012-05. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-01. Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm3545

    DOI

    http://dx.doi.org/10.1038/nrm3545

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007075159

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23524488


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Communication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Harvard Medical School, Boston Children's Hospital, Division of Newborn Medicine, 61 Binney Street, Enders 908, Boston, Massachusetts 02115, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Badeaux", 
            "givenName": "Aimee I.", 
            "id": "sg:person.01323016173.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323016173.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Harvard Medical School, Boston Children's Hospital, Division of Newborn Medicine, 61 Binney Street, Enders 908, Boston, Massachusetts 02115, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shi", 
            "givenName": "Yang", 
            "id": "sg:person.014540611514.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014540611514.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature10860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000103968", 
              "https://doi.org/10.1038/nature10860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000136134", 
              "https://doi.org/10.1038/nrd1902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000136134", 
              "https://doi.org/10.1038/nrd1902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20091856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000222388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20091856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000222388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20091856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000222388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2011.03.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001557969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci57477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001905247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80256-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001935955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2012.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002851493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003566897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-011-0729-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004255685", 
              "https://doi.org/10.1007/s00702-011-0729-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004332265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004378663", 
              "https://doi.org/10.1038/nature07280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0011333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004662125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005120733", 
              "https://doi.org/10.1038/ni.1968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005120733", 
              "https://doi.org/10.1038/ni.1968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.163667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005152515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)01064-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005877223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006017596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20090142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006816708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20090142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006816708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20090142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006816708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a005744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007248618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007265765", 
              "https://doi.org/10.1038/nature07954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007265765", 
              "https://doi.org/10.1038/nature07954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0810362106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007430286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.06.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007749925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007776380", 
              "https://doi.org/10.1038/nsmb.2353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0610792104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008163336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.12.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008557307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(01)00404-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008642079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2012.124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009792965", 
              "https://doi.org/10.1038/npp.2012.124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1206034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010212125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.2011.76.010975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011174549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m110.004796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012424593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.05631-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014296286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014519203", 
              "https://doi.org/10.1038/nature02017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014519203", 
              "https://doi.org/10.1038/nature02017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1227166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014700901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2011.08.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014700931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2012.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015932687", 
              "https://doi.org/10.1038/npp.2012.79"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0954422411000102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016569952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejmg.2012.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016591967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017016392", 
              "https://doi.org/10.1038/ncb2139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0022785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017209801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1233423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018080417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m900087-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018458276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.04.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018466639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018514185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019036471", 
              "https://doi.org/10.1038/nature10656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1284005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019430805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019641428", 
              "https://doi.org/10.1038/ncb1674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2008-9-10-r149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020767279", 
              "https://doi.org/10.1186/gb-2008-9-10-r149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020977367", 
              "https://doi.org/10.1038/nature03117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020977367", 
              "https://doi.org/10.1038/nature03117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021031479", 
              "https://doi.org/10.1038/nature07730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.02.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021045555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021177784", 
              "https://doi.org/10.1038/nature09350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021243466", 
              "https://doi.org/10.1038/ncomms1549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.333922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021402930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.15.6592-6602.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022962500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.271163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023488929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023605065", 
              "https://doi.org/10.1038/nature09272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023605065", 
              "https://doi.org/10.1038/nature09272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi.11.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023623661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.07.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023853635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.12.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024615991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-061809-175347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024925409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/47412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025852070", 
              "https://doi.org/10.1038/47412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/47412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025852070", 
              "https://doi.org/10.1038/47412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2011.284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026103190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027079838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027113143", 
              "https://doi.org/10.1038/nature10989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2011.04.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027371105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1202663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027415734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.065524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027514716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027670327", 
              "https://doi.org/10.1038/nature06092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2011.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028756238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1118947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029113782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029193341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029193341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029193341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029600804", 
              "https://doi.org/10.1038/nsmb.1939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029604077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1984210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029683556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030427346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.02.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030438526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.947102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030570608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030879226", 
              "https://doi.org/10.1038/ncb2228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2012.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030915584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2011.391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030997622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.07.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031153954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.10.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031224841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.330910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031331156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2004.029439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031465046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031489814", 
              "https://doi.org/10.1038/nrc3220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.188359.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031757100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032284905", 
              "https://doi.org/10.1038/ncb2116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032284905", 
              "https://doi.org/10.1038/ncb2116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2011.32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032777320", 
              "https://doi.org/10.1038/cr.2011.32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2011.32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032777320", 
              "https://doi.org/10.1038/cr.2011.32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neures.2010.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033041740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033071584", 
              "https://doi.org/10.1038/nsmb1338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.11.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033482668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.03.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033950501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)01196-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034737633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035041496", 
              "https://doi.org/10.1038/nrm3334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035904234", 
              "https://doi.org/10.1038/nature08839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035904234", 
              "https://doi.org/10.1038/nature08839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.04.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036521101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037479810", 
              "https://doi.org/10.1038/nsmb.2310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.6.5.15221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037896771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038289079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039241885", 
              "https://doi.org/10.1038/nature10892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039702446", 
              "https://doi.org/10.1038/nature07249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040565980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041742659", 
              "https://doi.org/10.1038/nrg2957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1012798108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042016682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c700192200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042553327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042692076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.07.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043249069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.03.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043364389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2011.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043545118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044259768", 
              "https://doi.org/10.1038/nature10572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044259768", 
              "https://doi.org/10.1038/nature10572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-8935-3-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044711810", 
              "https://doi.org/10.1186/1756-8935-3-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80718-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044824643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045258860", 
              "https://doi.org/10.1038/nature10861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045426741", 
              "https://doi.org/10.1038/nrg3173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045727917", 
              "https://doi.org/10.1038/nrm3288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045775370", 
              "https://doi.org/10.1038/nrm3048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046818300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00118-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046846916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1016071107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047051560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047120165", 
              "https://doi.org/10.1038/nsmb.2070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047759092", 
              "https://doi.org/10.1038/nature06166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.04.050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048035660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m900238-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048101814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048357777", 
              "https://doi.org/10.1038/nsmb.1568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2009.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048455603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2010.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049102336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.447007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049155547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi.11.21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049592835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049642587", 
              "https://doi.org/10.1038/nature08448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049642587", 
              "https://doi.org/10.1038/nature08448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-090711-093103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049877148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049984554", 
              "https://doi.org/10.1038/nature09589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049984554", 
              "https://doi.org/10.1038/nature09589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052015012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053274190", 
              "https://doi.org/10.1038/nature07273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2009.195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053643831", 
              "https://doi.org/10.1038/nrendo.2009.195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2009.195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053643831", 
              "https://doi.org/10.1038/nrendo.2009.195"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-04", 
        "datePublishedReg": "2013-04-01", 
        "description": "Cells of a multicellular organism, all containing nearly identical genetic information, respond to differentiation cues in variable ways. In addition, cells are plastic, able to execute their specialized function while maintaining the ability to adapt to environmental changes. This is achieved through multiple mechanisms, including the direct regulation of chromatin-based processes in response to stimuli. How signal transduction pathways directly communicate with chromatin to change the epigenetic landscape is poorly understood. The preponderance of covalent modifications on histone tails coupled with a relatively small number of functional outputs raises the possibility that chromatin acts as a site of signal integration and storage.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrm3545", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2518396", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2515828", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2685688", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2552601", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2478490", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1023609", 
            "issn": [
              "1471-0072", 
              "1471-0080"
            ], 
            "name": "Nature Reviews Molecular Cell Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Emerging roles for chromatin as a signal integration and storage platform", 
        "pagination": "211", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "21b3f26d60543145f1eb3d18888cad0901aee58fd354ca05fdb6157aef6f55d5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23524488"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100962782"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrm3545"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007075159"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrm3545", 
          "https://app.dimensions.ai/details/publication/pub.1007075159"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nrm3545"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrm3545'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrm3545'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrm3545'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrm3545'


     

    This table displays all metadata directly associated to this object as RDF triples.

    565 TRIPLES      21 PREDICATES      170 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrm3545 schema:about N21eba7e2f69b4236951327f82559188e
    2 N2ff002cb7ce143a38a6cad5eb5bb358f
    3 N544ed9e2c27845348e762aa117fc01d7
    4 N5d65ad12b4ba4fe8849efbdf65f05216
    5 N61ac8bba78234d3fad9923d70dc9b356
    6 N74db73fe40d646f48c192bf0f5e827f4
    7 N9874176002fe413c92898278dde2e15c
    8 Na53e08aaad5d488f8b211e19b70f9db1
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author N081c8c58155f4dc19be838ed090c2ee0
    12 schema:citation sg:pub.10.1007/s00702-011-0729-z
    13 sg:pub.10.1038/47412
    14 sg:pub.10.1038/cr.2011.32
    15 sg:pub.10.1038/nature02017
    16 sg:pub.10.1038/nature03117
    17 sg:pub.10.1038/nature06092
    18 sg:pub.10.1038/nature06166
    19 sg:pub.10.1038/nature07249
    20 sg:pub.10.1038/nature07273
    21 sg:pub.10.1038/nature07280
    22 sg:pub.10.1038/nature07730
    23 sg:pub.10.1038/nature07954
    24 sg:pub.10.1038/nature08448
    25 sg:pub.10.1038/nature08839
    26 sg:pub.10.1038/nature09272
    27 sg:pub.10.1038/nature09350
    28 sg:pub.10.1038/nature09589
    29 sg:pub.10.1038/nature10572
    30 sg:pub.10.1038/nature10656
    31 sg:pub.10.1038/nature10860
    32 sg:pub.10.1038/nature10861
    33 sg:pub.10.1038/nature10892
    34 sg:pub.10.1038/nature10989
    35 sg:pub.10.1038/ncb1674
    36 sg:pub.10.1038/ncb2116
    37 sg:pub.10.1038/ncb2139
    38 sg:pub.10.1038/ncb2228
    39 sg:pub.10.1038/ncomms1549
    40 sg:pub.10.1038/ni.1968
    41 sg:pub.10.1038/npp.2012.124
    42 sg:pub.10.1038/npp.2012.79
    43 sg:pub.10.1038/nrc3220
    44 sg:pub.10.1038/nrd1902
    45 sg:pub.10.1038/nrendo.2009.195
    46 sg:pub.10.1038/nrg2957
    47 sg:pub.10.1038/nrg3173
    48 sg:pub.10.1038/nrm3048
    49 sg:pub.10.1038/nrm3288
    50 sg:pub.10.1038/nrm3334
    51 sg:pub.10.1038/nsmb.1568
    52 sg:pub.10.1038/nsmb.1939
    53 sg:pub.10.1038/nsmb.2070
    54 sg:pub.10.1038/nsmb.2310
    55 sg:pub.10.1038/nsmb.2353
    56 sg:pub.10.1038/nsmb1338
    57 sg:pub.10.1186/1756-8935-3-22
    58 sg:pub.10.1186/gb-2008-9-10-r149
    59 https://doi.org/10.1016/j.ajhg.2012.05.003
    60 https://doi.org/10.1016/j.bbrc.2011.04.115
    61 https://doi.org/10.1016/j.ccr.2010.12.020
    62 https://doi.org/10.1016/j.cell.2006.02.041
    63 https://doi.org/10.1016/j.cell.2006.10.002
    64 https://doi.org/10.1016/j.cell.2007.02.017
    65 https://doi.org/10.1016/j.cell.2009.04.050
    66 https://doi.org/10.1016/j.cell.2009.07.031
    67 https://doi.org/10.1016/j.cell.2011.03.053
    68 https://doi.org/10.1016/j.cell.2011.04.021
    69 https://doi.org/10.1016/j.cell.2011.07.025
    70 https://doi.org/10.1016/j.cell.2011.10.053
    71 https://doi.org/10.1016/j.cell.2012.07.018
    72 https://doi.org/10.1016/j.cellsig.2011.08.019
    73 https://doi.org/10.1016/j.cmet.2012.06.001
    74 https://doi.org/10.1016/j.ejmg.2012.01.004
    75 https://doi.org/10.1016/j.expneurol.2011.03.022
    76 https://doi.org/10.1016/j.febslet.2011.04.047
    77 https://doi.org/10.1016/j.immuni.2012.03.013
    78 https://doi.org/10.1016/j.jmb.2011.12.001
    79 https://doi.org/10.1016/j.molcel.2006.10.011
    80 https://doi.org/10.1016/j.molcel.2007.06.026
    81 https://doi.org/10.1016/j.molcel.2008.07.002
    82 https://doi.org/10.1016/j.molcel.2008.12.013
    83 https://doi.org/10.1016/j.molcel.2010.11.024
    84 https://doi.org/10.1016/j.molcel.2011.03.022
    85 https://doi.org/10.1016/j.neures.2010.12.007
    86 https://doi.org/10.1016/j.neuron.2011.05.019
    87 https://doi.org/10.1016/j.neuron.2012.02.021
    88 https://doi.org/10.1016/j.stem.2010.08.013
    89 https://doi.org/10.1016/j.tibs.2010.05.006
    90 https://doi.org/10.1016/s0092-8674(00)00118-5
    91 https://doi.org/10.1016/s0092-8674(00)80718-7
    92 https://doi.org/10.1016/s0092-8674(02)01196-0
    93 https://doi.org/10.1016/s0092-8674(03)01064-x
    94 https://doi.org/10.1016/s1097-2765(00)80256-7
    95 https://doi.org/10.1016/s1097-2765(01)00404-x
    96 https://doi.org/10.1017/s0954422411000102
    97 https://doi.org/10.1038/emboj.2011.284
    98 https://doi.org/10.1038/emboj.2011.391
    99 https://doi.org/10.1038/embor.2009.221
    100 https://doi.org/10.1038/embor.2011.43
    101 https://doi.org/10.1042/bj20090142
    102 https://doi.org/10.1042/bj20091856
    103 https://doi.org/10.1073/pnas.0610792104
    104 https://doi.org/10.1073/pnas.0810362106
    105 https://doi.org/10.1073/pnas.1012798108
    106 https://doi.org/10.1073/pnas.1016071107
    107 https://doi.org/10.1074/jbc.c700192200
    108 https://doi.org/10.1074/jbc.m109.065524
    109 https://doi.org/10.1074/jbc.m110.163667
    110 https://doi.org/10.1074/jbc.m111.271163
    111 https://doi.org/10.1074/jbc.m111.330910
    112 https://doi.org/10.1074/jbc.m111.333922
    113 https://doi.org/10.1074/mcp.m110.004796
    114 https://doi.org/10.1074/mcp.m900087-mcp200
    115 https://doi.org/10.1074/mcp.m900238-mcp200
    116 https://doi.org/10.1093/emboj/cdg621
    117 https://doi.org/10.1093/nar/gkm726
    118 https://doi.org/10.1097/ypg.0b013e32833a2080
    119 https://doi.org/10.1101/cshperspect.a005744
    120 https://doi.org/10.1101/gad.1284005
    121 https://doi.org/10.1101/gad.188359.112
    122 https://doi.org/10.1101/gad.1984210
    123 https://doi.org/10.1101/gad.447007
    124 https://doi.org/10.1101/gad.947102
    125 https://doi.org/10.1101/sqb.2011.76.010975
    126 https://doi.org/10.1126/science.1118947
    127 https://doi.org/10.1126/science.1202663
    128 https://doi.org/10.1126/science.1206034
    129 https://doi.org/10.1126/science.1219651
    130 https://doi.org/10.1126/science.1227166
    131 https://doi.org/10.1126/science.1233423
    132 https://doi.org/10.1128/mcb.05631-11
    133 https://doi.org/10.1128/mcb.25.15.6592-6602.2005
    134 https://doi.org/10.1136/jmg.2004.029439
    135 https://doi.org/10.1146/annurev-biochem-061809-175347
    136 https://doi.org/10.1146/annurev-biochem-090711-093103
    137 https://doi.org/10.1158/0008-5472.can-09-2942
    138 https://doi.org/10.1172/jci57477
    139 https://doi.org/10.1371/journal.pone.0010042
    140 https://doi.org/10.1371/journal.pone.0011333
    141 https://doi.org/10.1371/journal.pone.0022785
    142 https://doi.org/10.2217/epi.11.14
    143 https://doi.org/10.2217/epi.11.21
    144 https://doi.org/10.4161/epi.6.5.15221
    145 schema:datePublished 2013-04
    146 schema:datePublishedReg 2013-04-01
    147 schema:description Cells of a multicellular organism, all containing nearly identical genetic information, respond to differentiation cues in variable ways. In addition, cells are plastic, able to execute their specialized function while maintaining the ability to adapt to environmental changes. This is achieved through multiple mechanisms, including the direct regulation of chromatin-based processes in response to stimuli. How signal transduction pathways directly communicate with chromatin to change the epigenetic landscape is poorly understood. The preponderance of covalent modifications on histone tails coupled with a relatively small number of functional outputs raises the possibility that chromatin acts as a site of signal integration and storage.
    148 schema:genre research_article
    149 schema:inLanguage en
    150 schema:isAccessibleForFree true
    151 schema:isPartOf N46819eae999647e39ac70151f7bb5348
    152 N98e1f428356246eb86d29dcac170cbf4
    153 sg:journal.1023609
    154 schema:name Emerging roles for chromatin as a signal integration and storage platform
    155 schema:pagination 211
    156 schema:productId N3e3a485f53ec433b9f1a234726c1daa6
    157 N681b6a5981484dc2ac8abce3f2603391
    158 N6aef9591343f4240ad2ebfb7dfd0876a
    159 Nd1709fdd96da4e96bdc6c7b9f3a4c7e5
    160 Ne0aee7b343db4df9a6fd13f084b27895
    161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007075159
    162 https://doi.org/10.1038/nrm3545
    163 schema:sdDatePublished 2019-04-10T17:20
    164 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    165 schema:sdPublisher Nab254208134e47ac9c09a681d117bba5
    166 schema:url https://www.nature.com/articles/nrm3545
    167 sgo:license sg:explorer/license/
    168 sgo:sdDataset articles
    169 rdf:type schema:ScholarlyArticle
    170 N081c8c58155f4dc19be838ed090c2ee0 rdf:first sg:person.01323016173.21
    171 rdf:rest N202f12b00d494b58977c6d54be1497bc
    172 N202f12b00d494b58977c6d54be1497bc rdf:first sg:person.014540611514.83
    173 rdf:rest rdf:nil
    174 N21eba7e2f69b4236951327f82559188e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Methylation
    176 rdf:type schema:DefinedTerm
    177 N2ff002cb7ce143a38a6cad5eb5bb358f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Models, Genetic
    179 rdf:type schema:DefinedTerm
    180 N3e3a485f53ec433b9f1a234726c1daa6 schema:name nlm_unique_id
    181 schema:value 100962782
    182 rdf:type schema:PropertyValue
    183 N46819eae999647e39ac70151f7bb5348 schema:volumeNumber 14
    184 rdf:type schema:PublicationVolume
    185 N544ed9e2c27845348e762aa117fc01d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Humans
    187 rdf:type schema:DefinedTerm
    188 N5d65ad12b4ba4fe8849efbdf65f05216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Chromatin
    190 rdf:type schema:DefinedTerm
    191 N61ac8bba78234d3fad9923d70dc9b356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Histones
    193 rdf:type schema:DefinedTerm
    194 N681b6a5981484dc2ac8abce3f2603391 schema:name dimensions_id
    195 schema:value pub.1007075159
    196 rdf:type schema:PropertyValue
    197 N6aef9591343f4240ad2ebfb7dfd0876a schema:name readcube_id
    198 schema:value 21b3f26d60543145f1eb3d18888cad0901aee58fd354ca05fdb6157aef6f55d5
    199 rdf:type schema:PropertyValue
    200 N7018aef10c5d49d58a2e83c296e40db9 schema:name Harvard Medical School, Boston Children's Hospital, Division of Newborn Medicine, 61 Binney Street, Enders 908, Boston, Massachusetts 02115, USA.
    201 rdf:type schema:Organization
    202 N74db73fe40d646f48c192bf0f5e827f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Cell Communication
    204 rdf:type schema:DefinedTerm
    205 N9874176002fe413c92898278dde2e15c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Epigenesis, Genetic
    207 rdf:type schema:DefinedTerm
    208 N98e1f428356246eb86d29dcac170cbf4 schema:issueNumber 4
    209 rdf:type schema:PublicationIssue
    210 Na53e08aaad5d488f8b211e19b70f9db1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Signal Transduction
    212 rdf:type schema:DefinedTerm
    213 Na8ce67fecfb24388a3854b0f43f9496a schema:name Harvard Medical School, Boston Children's Hospital, Division of Newborn Medicine, 61 Binney Street, Enders 908, Boston, Massachusetts 02115, USA.
    214 rdf:type schema:Organization
    215 Nab254208134e47ac9c09a681d117bba5 schema:name Springer Nature - SN SciGraph project
    216 rdf:type schema:Organization
    217 Nd1709fdd96da4e96bdc6c7b9f3a4c7e5 schema:name doi
    218 schema:value 10.1038/nrm3545
    219 rdf:type schema:PropertyValue
    220 Ne0aee7b343db4df9a6fd13f084b27895 schema:name pubmed_id
    221 schema:value 23524488
    222 rdf:type schema:PropertyValue
    223 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Biological Sciences
    225 rdf:type schema:DefinedTerm
    226 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    227 schema:name Genetics
    228 rdf:type schema:DefinedTerm
    229 sg:grant.2478490 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm3545
    230 rdf:type schema:MonetaryGrant
    231 sg:grant.2515828 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm3545
    232 rdf:type schema:MonetaryGrant
    233 sg:grant.2518396 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm3545
    234 rdf:type schema:MonetaryGrant
    235 sg:grant.2552601 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm3545
    236 rdf:type schema:MonetaryGrant
    237 sg:grant.2685688 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm3545
    238 rdf:type schema:MonetaryGrant
    239 sg:journal.1023609 schema:issn 1471-0072
    240 1471-0080
    241 schema:name Nature Reviews Molecular Cell Biology
    242 rdf:type schema:Periodical
    243 sg:person.01323016173.21 schema:affiliation N7018aef10c5d49d58a2e83c296e40db9
    244 schema:familyName Badeaux
    245 schema:givenName Aimee I.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323016173.21
    247 rdf:type schema:Person
    248 sg:person.014540611514.83 schema:affiliation Na8ce67fecfb24388a3854b0f43f9496a
    249 schema:familyName Shi
    250 schema:givenName Yang
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014540611514.83
    252 rdf:type schema:Person
    253 sg:pub.10.1007/s00702-011-0729-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004255685
    254 https://doi.org/10.1007/s00702-011-0729-z
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/47412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025852070
    257 https://doi.org/10.1038/47412
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/cr.2011.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032777320
    260 https://doi.org/10.1038/cr.2011.32
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nature02017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014519203
    263 https://doi.org/10.1038/nature02017
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature03117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020977367
    266 https://doi.org/10.1038/nature03117
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature06092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027670327
    269 https://doi.org/10.1038/nature06092
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature06166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047759092
    272 https://doi.org/10.1038/nature06166
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature07249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039702446
    275 https://doi.org/10.1038/nature07249
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nature07273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053274190
    278 https://doi.org/10.1038/nature07273
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nature07280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004378663
    281 https://doi.org/10.1038/nature07280
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nature07730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021031479
    284 https://doi.org/10.1038/nature07730
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nature07954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007265765
    287 https://doi.org/10.1038/nature07954
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nature08448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049642587
    290 https://doi.org/10.1038/nature08448
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/nature08839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035904234
    293 https://doi.org/10.1038/nature08839
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nature09272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023605065
    296 https://doi.org/10.1038/nature09272
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nature09350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177784
    299 https://doi.org/10.1038/nature09350
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nature09589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049984554
    302 https://doi.org/10.1038/nature09589
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/nature10572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044259768
    305 https://doi.org/10.1038/nature10572
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/nature10656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019036471
    308 https://doi.org/10.1038/nature10656
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/nature10860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000103968
    311 https://doi.org/10.1038/nature10860
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nature10861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045258860
    314 https://doi.org/10.1038/nature10861
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature10892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039241885
    317 https://doi.org/10.1038/nature10892
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nature10989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027113143
    320 https://doi.org/10.1038/nature10989
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ncb1674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019641428
    323 https://doi.org/10.1038/ncb1674
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/ncb2116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032284905
    326 https://doi.org/10.1038/ncb2116
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/ncb2139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017016392
    329 https://doi.org/10.1038/ncb2139
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/ncb2228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030879226
    332 https://doi.org/10.1038/ncb2228
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/ncomms1549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021243466
    335 https://doi.org/10.1038/ncomms1549
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/ni.1968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005120733
    338 https://doi.org/10.1038/ni.1968
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/npp.2012.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009792965
    341 https://doi.org/10.1038/npp.2012.124
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/npp.2012.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015932687
    344 https://doi.org/10.1038/npp.2012.79
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nrc3220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031489814
    347 https://doi.org/10.1038/nrc3220
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nrd1902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000136134
    350 https://doi.org/10.1038/nrd1902
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/nrendo.2009.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053643831
    353 https://doi.org/10.1038/nrendo.2009.195
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/nrg2957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041742659
    356 https://doi.org/10.1038/nrg2957
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nrg3173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045426741
    359 https://doi.org/10.1038/nrg3173
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nrm3048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045775370
    362 https://doi.org/10.1038/nrm3048
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/nrm3288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045727917
    365 https://doi.org/10.1038/nrm3288
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/nrm3334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035041496
    368 https://doi.org/10.1038/nrm3334
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/nsmb.1568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048357777
    371 https://doi.org/10.1038/nsmb.1568
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/nsmb.1939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029600804
    374 https://doi.org/10.1038/nsmb.1939
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/nsmb.2070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047120165
    377 https://doi.org/10.1038/nsmb.2070
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/nsmb.2310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037479810
    380 https://doi.org/10.1038/nsmb.2310
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/nsmb.2353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007776380
    383 https://doi.org/10.1038/nsmb.2353
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/nsmb1338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033071584
    386 https://doi.org/10.1038/nsmb1338
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1186/1756-8935-3-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044711810
    389 https://doi.org/10.1186/1756-8935-3-22
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1186/gb-2008-9-10-r149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020767279
    392 https://doi.org/10.1186/gb-2008-9-10-r149
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/j.ajhg.2012.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030915584
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/j.bbrc.2011.04.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036521101
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/j.ccr.2010.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024615991
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/j.cell.2006.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029604077
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/j.cell.2007.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021045555
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/j.cell.2009.04.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048035660
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/j.cell.2009.07.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043249069
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/j.cell.2011.03.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043364389
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/j.cell.2011.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018466639
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/j.cell.2011.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031153954
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/j.cell.2011.10.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031224841
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/j.cell.2012.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023853635
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/j.cellsig.2011.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014700931
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.cmet.2012.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002851493
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/j.ejmg.2012.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016591967
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/j.expneurol.2011.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001557969
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1016/j.febslet.2011.04.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027371105
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1016/j.immuni.2012.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006017596
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1016/j.jmb.2011.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043545118
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1016/j.molcel.2006.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042692076
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/j.molcel.2007.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007749925
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/j.molcel.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052015012
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/j.molcel.2008.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008557307
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/j.molcel.2010.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482668
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1016/j.molcel.2011.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033950501
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1016/j.neures.2010.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033041740
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1016/j.neuron.2011.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027079838
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1016/j.neuron.2012.02.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030438526
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1016/j.stem.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018514185
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1016/j.tibs.2010.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049102336
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1016/s0092-8674(00)00118-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046846916
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1016/s0092-8674(00)80718-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044824643
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1016/s0092-8674(02)01196-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034737633
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1016/s0092-8674(03)01064-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005877223
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1016/s1097-2765(00)80256-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001935955
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1016/s1097-2765(01)00404-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008642079
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1017/s0954422411000102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016569952
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1038/emboj.2011.284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026103190
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1038/emboj.2011.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030997622
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1038/embor.2009.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048455603
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1038/embor.2011.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028756238
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1042/bj20090142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006816708
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1042/bj20091856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000222388
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1073/pnas.0610792104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008163336
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1073/pnas.0810362106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007430286
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1073/pnas.1012798108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042016682
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1073/pnas.1016071107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047051560
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1074/jbc.c700192200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042553327
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1074/jbc.m109.065524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027514716
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1074/jbc.m110.163667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005152515
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1074/jbc.m111.271163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023488929
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1074/jbc.m111.330910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031331156
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1074/jbc.m111.333922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021402930
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1074/mcp.m110.004796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012424593
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1074/mcp.m900087-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458276
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1074/mcp.m900238-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048101814
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1093/emboj/cdg621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038289079
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1093/nar/gkm726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565980
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1097/ypg.0b013e32833a2080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029193341
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1101/cshperspect.a005744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007248618
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1101/gad.1284005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019430805
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1101/gad.188359.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031757100
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1101/gad.1984210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029683556
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1101/gad.447007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049155547
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1101/gad.947102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030570608
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1101/sqb.2011.76.010975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011174549
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1126/science.1118947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029113782
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1126/science.1202663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027415734
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1126/science.1206034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010212125
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1126/science.1219651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046818300
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1126/science.1227166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014700901
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1126/science.1233423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018080417
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1128/mcb.05631-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014296286
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1128/mcb.25.15.6592-6602.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022962500
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1136/jmg.2004.029439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031465046
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1146/annurev-biochem-061809-175347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024925409
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1146/annurev-biochem-090711-093103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049877148
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1158/0008-5472.can-09-2942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003566897
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1172/jci57477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001905247
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1371/journal.pone.0010042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004332265
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1371/journal.pone.0011333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004662125
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1371/journal.pone.0022785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017209801
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.2217/epi.11.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023623661
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.2217/epi.11.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049592835
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.4161/epi.6.5.15221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037896771
    565 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...