TALENs: a widely applicable technology for targeted genome editing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01

AUTHORS

J. Keith Joung, Jeffry D. Sander

ABSTRACT

Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases. More... »

PAGES

49

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Molecular Cell Biology

    ISSUE

    1

    VOLUME

    14

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm3486

    DOI

    http://dx.doi.org/10.1038/nrm3486

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050461034

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23169466


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