Mitochondria as sensors and regulators of calcium signalling View Full Text


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Article Info

DATE

2012-09

AUTHORS

Rosario Rizzuto, Diego De Stefani, Anna Raffaello, Cristina Mammucari

ABSTRACT

During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca(2+) uptake was shown to control intracellular Ca(2+) signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca(2+) levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca(2+) transporters has been revealed, opening new perspectives for investigation and molecular intervention. More... »

PAGES

566

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm3412

    DOI

    http://dx.doi.org/10.1038/nrm3412

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020967684

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22850819


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