AMPK: a nutrient and energy sensor that maintains energy homeostasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

D. Grahame Hardie, Fiona A. Ross, Simon A. Hawley

ABSTRACT

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability. More... »

PAGES

251

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm3311

    DOI

    http://dx.doi.org/10.1038/nrm3311

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025864588

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22436748


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