Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration View Full Text


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Article Info

DATE

2011-01-21

AUTHORS

Chris Jopling, Stephanie Boue, Juan Carlos Izpisua Belmonte

ABSTRACT

Key PointsThe ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming.During dedifferentiation, a terminally differentiated cell reverts back to a less-differentiated stage from within its own lineage, which allows it to proliferate. Many regenerative processes have been associated with dedifferentiation.Transdifferentiation sees cells regress to a point when they can switch lineages or can also occur directly between two different cell types.Reprogramming aims to induce differentiated cells into reverting to pluripotency. From here, they can differentiate into almost any cell type.During dedifferentiation and transdifferentiation, well-defined intermediate cell types have been identified. The process of reprogramming seems to be largely stochastic.Dedifferentiation and transdifferentiation can be successfully achieved in vivo, and reprogramming facilitates genetic manipulation such as correcting disease-inducing mutations. More... »

PAGES

79-89

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