mTOR: from growth signal integration to cancer, diabetes and ageing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01

AUTHORS

Roberto Zoncu, Alejo Efeyan, David M. Sabatini

ABSTRACT

In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing. More... »

PAGES

21

References to SciGraph publications

  • 2003-07. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans in NATURE
  • 2004-12. The role of autophagy during the early neonatal starvation period in NATURE
  • 2006-07. A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast in NATURE CELL BIOLOGY
  • 2004-09. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity in NATURE
  • 2003-06. Rheb promotes cell growth as a component of the insulin/TOR signalling network in NATURE CELL BIOLOGY
  • 2003-06. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila in NATURE CELL BIOLOGY
  • 2003-12. Genetics: Influence of TOR kinase on lifespan in C. elegans in NATURE
  • 2004-11. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive in NATURE CELL BIOLOGY
  • 2003-06. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins in NATURE CELL BIOLOGY
  • 1994-06. A mammalian protein targeted by G1-arresting rapamycin–receptor complex in NATURE
  • 1995-12. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B in NATURE
  • 2004-12. Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1 in NATURE
  • 2009-05. Molecular mechanisms of mTOR-mediated translational control in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-07. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice in NATURE
  • 2008-12. TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells in BMC CANCER
  • 2008-12. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers in NATURE MEDICINE
  • 2010-03. The genetics of ageing in NATURE
  • 2007-03. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 in NATURE CELL BIOLOGY
  • 2008-09. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function in NATURE MEDICINE
  • 2004-03. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy in NATURE
  • 2007-10. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-01. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer in NATURE MEDICINE
  • 2002-09. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling in NATURE CELL BIOLOGY
  • 2010-12. Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element in BMC CELL BIOLOGY
  • 2006-05. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells in NATURE
  • 2009-12. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila in NATURE
  • 1995-10. Control of p70 S6 kinase by kinase activity of FRAP in vivo in NATURE
  • 2008-09. PI3K pathway alterations in cancer: variations on a theme in ONCOGENE
  • 2002-10. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 in NATURE GENETICS
  • 2004-06. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease in NATURE GENETICS
  • 2003-05. Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction in NATURE
  • 2010-06. Termination of autophagy and reformation of lysosomes regulated by mTOR in NATURE
  • 2002-09. Akt regulates growth by directly phosphorylating Tsc2 in NATURE CELL BIOLOGY
  • 2009-04. Autophagy regulates lipid metabolism in NATURE
  • 2007-10. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis in NATURE REVIEWS CANCER
  • 2010-02. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor in NATURE MEDICINE
  • 2006-10. Stress and mTORture signaling in ONCOGENE
  • 2006-09. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a in NATURE
  • 2007-11. mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex in NATURE
  • 2006-09. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing in NATURE
  • 2007-02. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans in NATURE
  • 2008-08. Regulation of TORC1 by Rag GTPases in nutrient response in NATURE CELL BIOLOGY
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    http://scigraph.springernature.com/pub.10.1038/nrm3025

    DOI

    http://dx.doi.org/10.1038/nrm3025

    DIMENSIONS

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    PUBMED

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