New functions of aminoacyl-tRNA synthetases beyond translation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09

AUTHORS

Min Guo, Xiang-Lei Yang, Paul Schimmel

ABSTRACT

Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation. More... »

PAGES

668

Journal

TITLE

Nature Reviews Molecular Cell Biology

ISSUE

9

VOLUME

11

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2956

    DOI

    http://dx.doi.org/10.1038/nrm2956

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004944088

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20700144


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