HSP90 at the hub of protein homeostasis: emerging mechanistic insights View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-07

AUTHORS

Mikko Taipale, Daniel F. Jarosz, Susan Lindquist

ABSTRACT

Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched in signal transducers, including kinases and transcription factors. Therefore, HSP90 regulates diverse cellular functions and exerts marked effects on normal biology, disease and evolutionary processes. Recent structural and functional analyses have provided new insights on the transcriptional and biochemical regulation of HSP90 and the structural dynamics it uses to act on a diverse client repertoire. Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions. More... »

PAGES

515

References to SciGraph publications

  • 2001-01. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins in NATURE CELL BIOLOGY
  • 2009-03. The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-01. Function and regulation of cullin–RING ubiquitin ligases in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-08. Protein quality control: chaperones culling corrupt conformations in NATURE CELL BIOLOGY
  • 2006-12. Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms in BMC GENOMICS
  • 2005-10. HSP90 and the chaperoning of cancer in NATURE REVIEWS CANCER
  • 2003-09. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors in NATURE
  • 2005-02. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007. Protein Misassembly in MOLECULAR ASPECTS OF THE STRESS RESPONSE: CHAPERONES, MEMBRANES AND NETWORKS
  • 2007-05. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses in NATURE IMMUNOLOGY
  • 1998-04. Dynamic activation of endothelial nitric oxide synthase by Hsp90 in NATURE
  • 2009-01. Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms in CELL STRESS AND CHAPERONES
  • 1986. Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90 in RETROVIRUSES 4
  • 2003-01. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution in NATURE GENETICS
  • 2010-02. Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons in NATURE
  • 2009-11. Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1978-10. Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA in NATURE
  • 2004-06. Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness in NATURE CELL BIOLOGY
  • 2008-02. The activity of hsp90α promoter is regulated by NF-κB transcription factors in ONCOGENE
  • 2009-03. Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-02. The small heat shock proteins and their clients in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1998-11. Hsp90 as a capacitor for morphological evolution in NATURE
  • 2002-06. Hsp90 as a capacitor of phenotypic variation in NATURE
  • 1992-03. A protein-folding reaction under kinetic control in NATURE
  • 2009-06. Chaperonin overexpression promotes genetic variation and enzyme evolution in NATURE
  • 2007-02. Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997-06. A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-06. Converging concepts of protein folding in vitro and in vivo in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-04. Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex in NATURE
  • 2008-12. Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1984-04. Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones in NATURE
  • 1997-05. Interaction of Hsp70 chaperones with substrates in NATURE STRUCTURAL & MOLECULAR BIOLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2918

    DOI

    http://dx.doi.org/10.1038/nrm2918

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019520858

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20531426


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