BRCA1 and its toolbox for the maintenance of genome integrity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-02

AUTHORS

Michael S.Y. Huen, Shirley M.H. Sy, Junjie Chen

ABSTRACT

The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response. More... »

PAGES

138-148

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2831

    DOI

    http://dx.doi.org/10.1038/nrm2831

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016970769

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20029420


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrm2831'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrm2831'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrm2831'

    RDF/XML is a standard XML format for linked data.

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