Non-muscle myosin II takes centre stage in cell adhesion and migration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-11

AUTHORS

Miguel Vicente-Manzanares, Xuefei Ma, Robert S. Adelstein, Alan Rick Horwitz

ABSTRACT

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and contractile properties and is regulated by the phosphorylation of its light and heavy chains. The three mammalian NM II isoforms have both overlapping and unique properties. Owing to its position downstream of convergent signalling pathways, NM II is central in the control of cell adhesion, cell migration and tissue architecture. Recent insight into the role of NM II in these processes has been gained from loss-of-function and mutant approaches, methods that quantitatively measure actin and adhesion dynamics and the discovery of NM II mutations that cause monogenic diseases. More... »

PAGES

778-790

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2786

    DOI

    http://dx.doi.org/10.1038/nrm2786

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018642484

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19851336


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