Beyond polymer polarity: how the cytoskeleton builds a polarized cell View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11

AUTHORS

Rong Li, Gregg G Gundersen

ABSTRACT

Cell polarity relies on the asymmetric organization of cellular components and structures. Actin and microtubules are well suited to provide the structural basis for cell polarization because of their inherent structural polarity along the polymer lattices and intrinsic dynamics that allow them to respond rapidly to polarity cues. In general, the actin cytoskeleton drives the symmetry-breaking process that enables the establishment of a polarized distribution of regulatory molecules, whereas microtubules build on this asymmetry and maintain the stability of the polarized organization. Crosstalk coordinates the functions of the two cytoskeletal systems. More... »

PAGES

860-873

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrm2522

DOI

http://dx.doi.org/10.1038/nrm2522

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010183417

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18946475


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