Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-05

AUTHORS

Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri, Michael P. Czech

ABSTRACT

Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. Here we postulate that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids. More... »

PAGES

367-377

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2391

    DOI

    http://dx.doi.org/10.1038/nrm2391

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032104004

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18401346


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