The BCL-2 protein family: opposing activities that mediate cell death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Richard J. Youle, Andreas Strasser

ABSTRACT

Key PointsB-cell lymphoma-2 (BCL-2) family proteins regulate programmed cell death. Some members of the family (such as BCL-2 and BCL-XL) inhibit apoptosis, whereas others (such as BAX and BAK) promote cell death.BH3-only proteins are a distinct and structurally diverse class of proteins that share one motif, the BH3 domain, with BCL-2 family proteins. BH3-only proteins serve as death sentinels and transmit a signal to promote apoptosis to the core BCL-2 family proteins.Various BH3-only proteins interact with specific subsets of anti-apoptotic BCL-2 family members, yielding combinatorial signalling pathways towards apoptosis.Different tissues die prematurely in mice that lack different anti-apoptotic BCL-2 family members. Knockout of certain BH3-only proteins can compensate for the specific tissue defects that are found in mice deficient in BCL-2 family members.At the onset of apoptosis, BAX and BAK undergo conformational changes, cause the outer membrane of the mitochondria to become permeable to various proteins and induce mitochondria to fragment into smaller units.The changes in mitochondria during apoptosis, especially the release of cytochrome c, result in the activation of caspase proteases that orchestrate the efficient dismantling of dying cells. More... »

PAGES

47-59

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Molecular Cell Biology

    ISSUE

    1

    VOLUME

    9

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2308

    DOI

    http://dx.doi.org/10.1038/nrm2308

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038545301

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18097445


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