The BCL-2 protein family: opposing activities that mediate cell death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Richard J. Youle, Andreas Strasser

ABSTRACT

Key PointsB-cell lymphoma-2 (BCL-2) family proteins regulate programmed cell death. Some members of the family (such as BCL-2 and BCL-XL) inhibit apoptosis, whereas others (such as BAX and BAK) promote cell death.BH3-only proteins are a distinct and structurally diverse class of proteins that share one motif, the BH3 domain, with BCL-2 family proteins. BH3-only proteins serve as death sentinels and transmit a signal to promote apoptosis to the core BCL-2 family proteins.Various BH3-only proteins interact with specific subsets of anti-apoptotic BCL-2 family members, yielding combinatorial signalling pathways towards apoptosis.Different tissues die prematurely in mice that lack different anti-apoptotic BCL-2 family members. Knockout of certain BH3-only proteins can compensate for the specific tissue defects that are found in mice deficient in BCL-2 family members.At the onset of apoptosis, BAX and BAK undergo conformational changes, cause the outer membrane of the mitochondria to become permeable to various proteins and induce mitochondria to fragment into smaller units.The changes in mitochondria during apoptosis, especially the release of cytochrome c, result in the activation of caspase proteases that orchestrate the efficient dismantling of dying cells. More... »

PAGES

47-59

References to SciGraph publications

  • 1990-11. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2 in NATURE
  • 2005-10-20. Promoting apoptosis as a strategy for cancer drug discovery in NATURE REVIEWS CANCER
  • 2005-02. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans in NATURE
  • 2002-02. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes in NATURE
  • 2005-05. Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3 in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2005-06-10. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK in CELL DEATH & DIFFERENTIATION
  • 1994-05. Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2 in NATURE
  • 2006-04-28. Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets in CELL DEATH & DIFFERENTIATION
  • 2007-02-26. The Bcl-2 apoptotic switch in cancer development and therapy in ONCOGENE
  • 2005-02-18. The role of BH3-only proteins in the immune system in NATURE REVIEWS IMMUNOLOGY
  • 2006-09-01. Elucidation of some Bax conformational changes through crystallization of an antibody–peptide complex in CELL DEATH & DIFFERENTIATION
  • 2002-09-25. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome in NATURE
  • 2006-05-19. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario in CELL DEATH & DIFFERENTIATION
  • 2006-05-26. Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum in CELL DEATH & DIFFERENTIATION
  • 2006-05-19. Regulated targeting of Bax and Bak to intracellular membranes during apoptosis in CELL DEATH & DIFFERENTIATION
  • 2006-06-09. Which came first, the cytochrome c release or the mitochondrial fission? in CELL DEATH & DIFFERENTIATION
  • 2005-07-15. Mitochondrial fission in apoptosis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1999-08. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis in NATURE
  • 2004-12-10. Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation in CELL DEATH & DIFFERENTIATION
  • 2006-10-01. Role of Bax and Bak in mitochondrial morphogenesis in NATURE
  • 2000-06. Molecular Evolution of Apoptotic Pathways: Cloning of Key Domains from Sponges (Bcl-2 Homology Domains and Death Domains) and Their Phylogenetic Relationships in JOURNAL OF MOLECULAR EVOLUTION
  • 2004-12-17. C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage in CELL DEATH & DIFFERENTIATION
  • 2007-04-08. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death in NATURE CELL BIOLOGY
  • 2006-08-04. Functional characterization of the Bcl-2 gene family in the zebrafish in CELL DEATH & DIFFERENTIATION
  • 1988-09. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells in NATURE
  • 1996-05. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death in NATURE
  • 2002-09-03. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis in NATURE IMMUNOLOGY
  • 1997-01. Bcl-xL forms an ion channel in synthetic lipid membranes in NATURE
  • 2006-11-19. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies in NATURE CELL BIOLOGY
  • Journal

    TITLE

    Nature Reviews Molecular Cell Biology

    ISSUE

    1

    VOLUME

    9

    Related Patents

  • Cancer Therapy With A Parvovirus Combined With A Bcl-2 Inhibitor
  • Pyrazol-3-Ones That Activate Pro-Apoptotic Bax
  • Bcl-2 Inhibitors
  • Pro-Drug Innovativo Micellare Su Backbone Polimerico Del Killer Tnf-Apoptosis Induced Ligand.
  • Bh4 Stabilized Peptides And Uses Thereof
  • Antagonists Of Bcl-2 And Uses Thereof In Induction Of Apoptosis
  • Interleukin-4 Receptor-Binding Fusion Proteins And Uses Thereof
  • Composition For Increasing Expression Of Pgc-1Α
  • Method And Compositions Comprising A Ct20 Peptide
  • Method Of Diagnosing, Treating And Determining Progression And Survival Of Cancer Cells Using Bcl-2 Antagonist Of Cell Death (Bad) Pathway Gene Signature
  • Cancer Therapy With A Parvovirus Combined With Bevacizumab
  • Treatment Of Tnf- Alpha Cytotoxicity
  • Hot Melt Extruded Solid Dispersions Containing A Bcl2 Inhibitor
  • Phenylsulfonamido-Benzofuran Derivatives And Uses Thereof In The Treatment Of Proliferative Diseases
  • Pyrazol-3-Ones That Activate Pro-Apototic Bax
  • Bh4 Stabilized Peptides And Uses Thereof
  • Bcl-2 Inhibitors
  • Composition For Increasing Expression Of Pgc-1a
  • Methods And Compositions Comprising A C-Terminal Bax Peptide
  • Small Molecule Inhibitors Of The Mcl-1 Oncoprotein And Uses Thereof
  • Inhibition Of Mcl-1 And/Or Bfl-1/A1
  • Peptides Binding To Bfl-1
  • Pyrazol-3-Ones That Activate Pro-Apoptotic Bax
  • Rnai-Based Method Of Drug Screening And Characterization
  • 1h-Pyrrolo[2,3-B]Pyridine Derivatives As Bcl-2 Inhibitors For The Treatment Of Neoplastic And Autoimmune Diseases
  • Peptides Binding To Bfl-1
  • Bcl-2 Inhibitors
  • Biomarkers For Treatment With Anti-Tubulin Chemotherapeutic Compounds
  • Inhibitors Of Bcl-2
  • Interleukin-4 Receptor-Binding Fusion Proteins And Uses Thereof
  • Inhibition Of Mcl-1 And/Or Bfl-1/A1
  • Bcl-W Polypeptides And Mimetics For Treating Or Preventing Chemotherapy-Induced Peripheral Neuropathy And Hearing Loss
  • Bax-Activating Cancer Therapeutics
  • Bcl-2 Inhibitors
  • Synthetic Lethality And The Treatment Of Cancer
  • Condensed Heterocyclic Derivatives As Bcl-2 Inhibitors For The Treatment Of Neoplastic Diseases
  • Interleukin-4 Receptor-Binding Fusion Proteins And Uses Thereof
  • Amphipathic And Other Double-Sided Alpha-Helix Mimetics Based On A 1,2-Diphenylacetylene Scaffold
  • Condensed Heterocycles As Bcl-2 Inhibitors
  • Methods For Treating Tyrosine-Kinase-Inhibitor-Resistant Malignancies In Patients With Genetic Polymorphisms Or Ahi1 Dysregulations Or Mutations Employing Dianhydrogalactitol, Diacetyldianhydrogalactitol, Dibromodulcitol, Or Analogs Or Derivatives Thereof
  • Cancer Therapy With A Parvovirus Combined With A Bcl-2 Inhibitor
  • Macrocyclic Mcl-1 Inhibitors And Methods Of Use
  • Compositions And Methods For Purifying Bax
  • Small Molecules For The Modulation Of Mcl-1 And Methods Of Modulating Cell Death, Cell Division, Cell Differentiation And Methods Of Treating Disorders
  • 1h-Pyrrolo[2,3-B]Pyridine Derivatives As Bcl-2 Inhibitors For The Treatment Of Neoplastic And Autoimmune Diseases
  • Phenylsulfonamido-Benzofuran Derivatives And Uses Thereof In The Treatment Of Proliferative Diseases
  • Interleukin-4 Receptor-Binding Fusion Proteins And Uses Thereof
  • Apogossypolone Derivatives As Anticancer Agents
  • Rnai Based Method Of Drug Screening And Characterization
  • Chemical Modulators Of Pro-Apoptotic Bax And Bcl-2 Polypeptides
  • Method Of Treating Bcl-2 Over-Expressing Disorders Using Arts Containing A Bh3-Like Domain
  • Rnai-Based Method Of Screening And Characterizing Drug Combinations
  • Methods And Compositions Comprising A C-Terminal Bax Peptide
  • Chemical Modulators Of Pro-Apoptotic Bax And Bcl-2 Polypeptides
  • Pyrazol-3-Ones That Activate Pro-Apoptotic Bax
  • Methods And Compositions Comprising A C-Terminal Bax Peptide
  • Predictive Markers For Taxane Responsiveness And Methods Of Use Thereof
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2308

    DOI

    http://dx.doi.org/10.1038/nrm2308

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038545301

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18097445


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phylogeny", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Tertiary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-bcl-2", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, 20892, Bethesda, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.416870.c", 
              "name": [
                "Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, 20892, Bethesda, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Youle", 
            "givenName": "Richard J.", 
            "id": "sg:person.01050464311.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050464311.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Walter and Eliza Hall Institute of Medical Research, 3050, Parkville, Melbourne, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1042.7", 
              "name": [
                "The Walter and Eliza Hall Institute of Medical Research, 3050, Parkville, Melbourne, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Strasser", 
            "givenName": "Andreas", 
            "id": "sg:person.01215767043.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215767043.67"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrc1736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032667203", 
              "https://doi.org/10.1038/nrc1736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/381335a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003038902", 
              "https://doi.org/10.1038/381335a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/348331a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019679922", 
              "https://doi.org/10.1038/348331a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049238352", 
              "https://doi.org/10.1038/sj.cdd.4401985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020174476", 
              "https://doi.org/10.1038/nature03316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/335440a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037003177", 
              "https://doi.org/10.1038/335440a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002966366", 
              "https://doi.org/10.1038/nrm1697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002390010055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031272939", 
              "https://doi.org/10.1007/s002390010055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045246322", 
              "https://doi.org/10.1038/nri1568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/385353a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027167416", 
              "https://doi.org/10.1038/385353a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415922a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040375797", 
              "https://doi.org/10.1038/415922a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-005-4543-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007776394", 
              "https://doi.org/10.1007/s00018-005-4543-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036530779", 
              "https://doi.org/10.1038/ni834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/369318a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045527465", 
              "https://doi.org/10.1038/369318a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013972371", 
              "https://doi.org/10.1038/sj.cdd.4401539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031431852", 
              "https://doi.org/10.1038/ncb1575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014618255", 
              "https://doi.org/10.1038/sj.cdd.4401688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006690598", 
              "https://doi.org/10.1038/sj.cdd.4401961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009667095", 
              "https://doi.org/10.1038/sj.cdd.4401537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026463999", 
              "https://doi.org/10.1038/sj.cdd.4402025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034839980", 
              "https://doi.org/10.1038/sj.cdd.4402016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029856193", 
              "https://doi.org/10.1038/sj.cdd.4401963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013847459", 
              "https://doi.org/10.1038/sj.cdd.4401934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009398987", 
              "https://doi.org/10.1038/nature05111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003659648", 
              "https://doi.org/10.1038/ncb1499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/23730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045115085", 
              "https://doi.org/10.1038/23730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033331489", 
              "https://doi.org/10.1038/sj.cdd.4401960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028014444", 
              "https://doi.org/10.1038/nature01101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022397510", 
              "https://doi.org/10.1038/sj.onc.1210220"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-01", 
        "datePublishedReg": "2008-01-01", 
        "description": "Key PointsB-cell lymphoma-2 (BCL-2) family proteins regulate programmed cell death. Some members of the family (such as BCL-2 and BCL-XL) inhibit apoptosis, whereas others (such as BAX and BAK) promote cell death.BH3-only proteins are a distinct and structurally diverse class of proteins that share one motif, the BH3 domain, with BCL-2 family proteins. BH3-only proteins serve as death sentinels and transmit a signal to promote apoptosis to the core BCL-2 family proteins.Various BH3-only proteins interact with specific subsets of anti-apoptotic BCL-2 family members, yielding combinatorial signalling pathways towards apoptosis.Different tissues die prematurely in mice that lack different anti-apoptotic BCL-2 family members. Knockout of certain BH3-only proteins can compensate for the specific tissue defects that are found in mice deficient in BCL-2 family members.At the onset of apoptosis, BAX and BAK undergo conformational changes, cause the outer membrane of the mitochondria to become permeable to various proteins and induce mitochondria to fragment into smaller units.The changes in mitochondria during apoptosis, especially the release of cytochrome c, result in the activation of caspase proteases that orchestrate the efficient dismantling of dying cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nrm2308", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2726247", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2721583", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1023609", 
            "issn": [
              "1471-0072", 
              "1471-0080"
            ], 
            "name": "Nature Reviews Molecular Cell Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "keywords": [
          "Bcl-2 family members", 
          "anti-apoptotic Bcl-2 family members", 
          "Bcl-2 family proteins", 
          "family proteins", 
          "cell death", 
          "Bcl-2 protein family", 
          "combinatorial signaling pathways", 
          "BH3-only proteins", 
          "onset of apoptosis", 
          "caspase proteases", 
          "certain BH3", 
          "protein family", 
          "BH3 domain", 
          "outer membrane", 
          "family members", 
          "specific tissue defects", 
          "signaling pathways", 
          "conformational changes", 
          "different tissues", 
          "cytochrome c", 
          "diverse class", 
          "protein", 
          "BH3", 
          "mitochondria", 
          "apoptosis", 
          "specific subset", 
          "members", 
          "efficient dismantling", 
          "family", 
          "Bak", 
          "motif", 
          "knockout", 
          "protease", 
          "Bax", 
          "pathway", 
          "mice", 
          "membrane", 
          "cells", 
          "activation", 
          "death", 
          "domain", 
          "tissue", 
          "sentinels", 
          "smaller units", 
          "activity", 
          "changes", 
          "defects", 
          "release", 
          "signals", 
          "subset", 
          "class", 
          "dismantling", 
          "onset", 
          "units", 
          "tissue defects"
        ], 
        "name": "The BCL-2 protein family: opposing activities that mediate cell death", 
        "pagination": "47-59", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038545301"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrm2308"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18097445"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrm2308", 
          "https://app.dimensions.ai/details/publication/pub.1038545301"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:52", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_452.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nrm2308"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrm2308'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrm2308'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrm2308'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrm2308'


     

    This table displays all metadata directly associated to this object as RDF triples.

    278 TRIPLES      21 PREDICATES      118 URIs      81 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrm2308 schema:about N3ec7f6596b75402299513eecbc7c1701
    2 N439bf48048984af589dec09ee46dfc7d
    3 N502339091a13413c8337d6911258dab5
    4 N57dbe1ae334d4a95a7ea1d510ba391be
    5 N638f3a5e4b0f424589996d8580c05099
    6 N6ead66f2ed384206b121526485fa41e7
    7 Ne09f292d464947378e21a7475df2c9b9
    8 Nfd3d0be3812646d680bde3ecca3e8cdd
    9 anzsrc-for:06
    10 anzsrc-for:0601
    11 schema:author Nafaab736ebc54763bc7513ba616f1b0a
    12 schema:citation sg:pub.10.1007/s00018-005-4543-3
    13 sg:pub.10.1007/s002390010055
    14 sg:pub.10.1038/23730
    15 sg:pub.10.1038/335440a0
    16 sg:pub.10.1038/348331a0
    17 sg:pub.10.1038/369318a0
    18 sg:pub.10.1038/381335a0
    19 sg:pub.10.1038/385353a0
    20 sg:pub.10.1038/415922a
    21 sg:pub.10.1038/nature01101
    22 sg:pub.10.1038/nature03316
    23 sg:pub.10.1038/nature05111
    24 sg:pub.10.1038/ncb1499
    25 sg:pub.10.1038/ncb1575
    26 sg:pub.10.1038/ni834
    27 sg:pub.10.1038/nrc1736
    28 sg:pub.10.1038/nri1568
    29 sg:pub.10.1038/nrm1697
    30 sg:pub.10.1038/sj.cdd.4401537
    31 sg:pub.10.1038/sj.cdd.4401539
    32 sg:pub.10.1038/sj.cdd.4401688
    33 sg:pub.10.1038/sj.cdd.4401934
    34 sg:pub.10.1038/sj.cdd.4401960
    35 sg:pub.10.1038/sj.cdd.4401961
    36 sg:pub.10.1038/sj.cdd.4401963
    37 sg:pub.10.1038/sj.cdd.4401985
    38 sg:pub.10.1038/sj.cdd.4402016
    39 sg:pub.10.1038/sj.cdd.4402025
    40 sg:pub.10.1038/sj.onc.1210220
    41 schema:datePublished 2008-01
    42 schema:datePublishedReg 2008-01-01
    43 schema:description Key PointsB-cell lymphoma-2 (BCL-2) family proteins regulate programmed cell death. Some members of the family (such as BCL-2 and BCL-XL) inhibit apoptosis, whereas others (such as BAX and BAK) promote cell death.BH3-only proteins are a distinct and structurally diverse class of proteins that share one motif, the BH3 domain, with BCL-2 family proteins. BH3-only proteins serve as death sentinels and transmit a signal to promote apoptosis to the core BCL-2 family proteins.Various BH3-only proteins interact with specific subsets of anti-apoptotic BCL-2 family members, yielding combinatorial signalling pathways towards apoptosis.Different tissues die prematurely in mice that lack different anti-apoptotic BCL-2 family members. Knockout of certain BH3-only proteins can compensate for the specific tissue defects that are found in mice deficient in BCL-2 family members.At the onset of apoptosis, BAX and BAK undergo conformational changes, cause the outer membrane of the mitochondria to become permeable to various proteins and induce mitochondria to fragment into smaller units.The changes in mitochondria during apoptosis, especially the release of cytochrome c, result in the activation of caspase proteases that orchestrate the efficient dismantling of dying cells.
    44 schema:genre article
    45 schema:isAccessibleForFree false
    46 schema:isPartOf N94d2048f8e68463384daa548c2f31ce2
    47 Nf1535a36a5304240b14cfbddc72cafba
    48 sg:journal.1023609
    49 schema:keywords BH3
    50 BH3 domain
    51 BH3-only proteins
    52 Bak
    53 Bax
    54 Bcl-2 family members
    55 Bcl-2 family proteins
    56 Bcl-2 protein family
    57 activation
    58 activity
    59 anti-apoptotic Bcl-2 family members
    60 apoptosis
    61 caspase proteases
    62 cell death
    63 cells
    64 certain BH3
    65 changes
    66 class
    67 combinatorial signaling pathways
    68 conformational changes
    69 cytochrome c
    70 death
    71 defects
    72 different tissues
    73 dismantling
    74 diverse class
    75 domain
    76 efficient dismantling
    77 family
    78 family members
    79 family proteins
    80 knockout
    81 members
    82 membrane
    83 mice
    84 mitochondria
    85 motif
    86 onset
    87 onset of apoptosis
    88 outer membrane
    89 pathway
    90 protease
    91 protein
    92 protein family
    93 release
    94 sentinels
    95 signaling pathways
    96 signals
    97 smaller units
    98 specific subset
    99 specific tissue defects
    100 subset
    101 tissue
    102 tissue defects
    103 units
    104 schema:name The BCL-2 protein family: opposing activities that mediate cell death
    105 schema:pagination 47-59
    106 schema:productId N3c88fbb35f0a417d9f1be1cb48047127
    107 Na47cb20bd8fa4a5fb6efdffe1b375829
    108 Nb1ce04e1242a4183b6af7de75edcf34f
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038545301
    110 https://doi.org/10.1038/nrm2308
    111 schema:sdDatePublished 2022-11-24T20:52
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher Ne9f07c83144948aaad5d6cce1736f2d8
    114 schema:url https://doi.org/10.1038/nrm2308
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N3c88fbb35f0a417d9f1be1cb48047127 schema:name pubmed_id
    119 schema:value 18097445
    120 rdf:type schema:PropertyValue
    121 N3ec7f6596b75402299513eecbc7c1701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Apoptosis
    123 rdf:type schema:DefinedTerm
    124 N439bf48048984af589dec09ee46dfc7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Proto-Oncogene Proteins c-bcl-2
    126 rdf:type schema:DefinedTerm
    127 N502339091a13413c8337d6911258dab5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Protein Structure, Tertiary
    129 rdf:type schema:DefinedTerm
    130 N57dbe1ae334d4a95a7ea1d510ba391be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Phylogeny
    132 rdf:type schema:DefinedTerm
    133 N638f3a5e4b0f424589996d8580c05099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Humans
    135 rdf:type schema:DefinedTerm
    136 N6ead66f2ed384206b121526485fa41e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Models, Molecular
    138 rdf:type schema:DefinedTerm
    139 N94d2048f8e68463384daa548c2f31ce2 schema:issueNumber 1
    140 rdf:type schema:PublicationIssue
    141 N9e8e081ea1da4e63ab47e32cd6ee7651 rdf:first sg:person.01215767043.67
    142 rdf:rest rdf:nil
    143 Na47cb20bd8fa4a5fb6efdffe1b375829 schema:name doi
    144 schema:value 10.1038/nrm2308
    145 rdf:type schema:PropertyValue
    146 Nafaab736ebc54763bc7513ba616f1b0a rdf:first sg:person.01050464311.94
    147 rdf:rest N9e8e081ea1da4e63ab47e32cd6ee7651
    148 Nb1ce04e1242a4183b6af7de75edcf34f schema:name dimensions_id
    149 schema:value pub.1038545301
    150 rdf:type schema:PropertyValue
    151 Ne09f292d464947378e21a7475df2c9b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Mitochondria
    153 rdf:type schema:DefinedTerm
    154 Ne9f07c83144948aaad5d6cce1736f2d8 schema:name Springer Nature - SN SciGraph project
    155 rdf:type schema:Organization
    156 Nf1535a36a5304240b14cfbddc72cafba schema:volumeNumber 9
    157 rdf:type schema:PublicationVolume
    158 Nfd3d0be3812646d680bde3ecca3e8cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Animals
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Biological Sciences
    163 rdf:type schema:DefinedTerm
    164 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Biochemistry and Cell Biology
    166 rdf:type schema:DefinedTerm
    167 sg:grant.2721583 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm2308
    168 rdf:type schema:MonetaryGrant
    169 sg:grant.2726247 http://pending.schema.org/fundedItem sg:pub.10.1038/nrm2308
    170 rdf:type schema:MonetaryGrant
    171 sg:journal.1023609 schema:issn 1471-0072
    172 1471-0080
    173 schema:name Nature Reviews Molecular Cell Biology
    174 schema:publisher Springer Nature
    175 rdf:type schema:Periodical
    176 sg:person.01050464311.94 schema:affiliation grid-institutes:grid.416870.c
    177 schema:familyName Youle
    178 schema:givenName Richard J.
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050464311.94
    180 rdf:type schema:Person
    181 sg:person.01215767043.67 schema:affiliation grid-institutes:grid.1042.7
    182 schema:familyName Strasser
    183 schema:givenName Andreas
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215767043.67
    185 rdf:type schema:Person
    186 sg:pub.10.1007/s00018-005-4543-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007776394
    187 https://doi.org/10.1007/s00018-005-4543-3
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s002390010055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031272939
    190 https://doi.org/10.1007/s002390010055
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/23730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045115085
    193 https://doi.org/10.1038/23730
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/335440a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037003177
    196 https://doi.org/10.1038/335440a0
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/348331a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019679922
    199 https://doi.org/10.1038/348331a0
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/369318a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045527465
    202 https://doi.org/10.1038/369318a0
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/381335a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003038902
    205 https://doi.org/10.1038/381335a0
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/385353a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027167416
    208 https://doi.org/10.1038/385353a0
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/415922a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040375797
    211 https://doi.org/10.1038/415922a
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature01101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028014444
    214 https://doi.org/10.1038/nature01101
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature03316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020174476
    217 https://doi.org/10.1038/nature03316
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature05111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009398987
    220 https://doi.org/10.1038/nature05111
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/ncb1499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003659648
    223 https://doi.org/10.1038/ncb1499
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/ncb1575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031431852
    226 https://doi.org/10.1038/ncb1575
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/ni834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036530779
    229 https://doi.org/10.1038/ni834
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nrc1736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032667203
    232 https://doi.org/10.1038/nrc1736
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nri1568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045246322
    235 https://doi.org/10.1038/nri1568
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nrm1697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002966366
    238 https://doi.org/10.1038/nrm1697
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/sj.cdd.4401537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009667095
    241 https://doi.org/10.1038/sj.cdd.4401537
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/sj.cdd.4401539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013972371
    244 https://doi.org/10.1038/sj.cdd.4401539
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/sj.cdd.4401688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014618255
    247 https://doi.org/10.1038/sj.cdd.4401688
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/sj.cdd.4401934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013847459
    250 https://doi.org/10.1038/sj.cdd.4401934
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/sj.cdd.4401960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033331489
    253 https://doi.org/10.1038/sj.cdd.4401960
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/sj.cdd.4401961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006690598
    256 https://doi.org/10.1038/sj.cdd.4401961
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/sj.cdd.4401963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029856193
    259 https://doi.org/10.1038/sj.cdd.4401963
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/sj.cdd.4401985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049238352
    262 https://doi.org/10.1038/sj.cdd.4401985
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/sj.cdd.4402016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034839980
    265 https://doi.org/10.1038/sj.cdd.4402016
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/sj.cdd.4402025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026463999
    268 https://doi.org/10.1038/sj.cdd.4402025
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/sj.onc.1210220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022397510
    271 https://doi.org/10.1038/sj.onc.1210220
    272 rdf:type schema:CreativeWork
    273 grid-institutes:grid.1042.7 schema:alternateName The Walter and Eliza Hall Institute of Medical Research, 3050, Parkville, Melbourne, Australia
    274 schema:name The Walter and Eliza Hall Institute of Medical Research, 3050, Parkville, Melbourne, Australia
    275 rdf:type schema:Organization
    276 grid-institutes:grid.416870.c schema:alternateName Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, 20892, Bethesda, Maryland, USA
    277 schema:name Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, 20892, Bethesda, Maryland, USA
    278 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...