Melanosomes — dark organelles enlighten endosomal membrane transport View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-10

AUTHORS

Graça Raposo, Michael S Marks

ABSTRACT

Melanosomes are tissue-specific lysosome-related organelles of pigment cells in which melanins are synthesized and stored. Analyses of the trafficking and fate of melanosomal components are beginning to reveal how melanosomes are formed through novel pathways from early endosomal intermediates. These studies unveil generalized structural and functional modifications of the endosomal system in specialized cells, and provide unexpected insights into the biogenesis of multivesicular bodies and how compartmentalization regulates protein refolding. Moreover, genetic disorders that affect the biogenesis of melanosomes and other lysosome-related organelles have shed light onto the molecular machinery that controls specialized endosomal sorting events. More... »

PAGES

786-797

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2258

    DOI

    http://dx.doi.org/10.1038/nrm2258

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005579140

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17878918


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