Analysis of protein complexes using mass spectrometry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-08

AUTHORS

Anne-Claude Gingras, Matthias Gstaiger, Brian Raught, Ruedi Aebersold

ABSTRACT

The versatile combination of affinity purification and mass spectrometry (AP-MS) has recently been applied to the detailed characterization of many protein complexes and large protein-interaction networks. The combination of AP-MS with other techniques, such as biochemical fractionation, intact mass measurement and chemical crosslinking, can help to decipher the supramolecular organization of protein complexes. AP-MS can also be combined with quantitative proteomics approaches to better understand the dynamics of protein-complex assembly. More... »

PAGES

645-654

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm2208

    DOI

    http://dx.doi.org/10.1038/nrm2208

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17593931


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