Poly(ADP-ribose): novel functions for an old molecule View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07

AUTHORS

Valérie Schreiber, Françoise Dantzer, Jean-Christophe Ame, Gilbert de Murcia

ABSTRACT

The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism. More... »

PAGES

517-528

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm1963

    DOI

    http://dx.doi.org/10.1038/nrm1963

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033444236

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16829982


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