Ubiquitin-binding domains View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

Linda Hicke, Heidi L Schubert, Christopher P Hill

ABSTRACT

Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-covalently bind to ubiquitin. These recently discovered motifs interpret and transmit information conferred by protein ubiquitylation to control various cellular events. Detailed molecular structures are known for a number of UBDs, but to understand their mechanism of action, we also need to know how binding specificity is determined, how ubiquitin binding is regulated, and the function of UBDs in the context of full-length proteins. Such knowledge will be key to our understanding of how ubiquitin regulates cellular proteins and processes. More... »

PAGES

610-621

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrm1701

    DOI

    http://dx.doi.org/10.1038/nrm1701

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020986269

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16064137


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