ADAMs: key components in EGFR signalling and development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01

AUTHORS

Carl P Blobel

ABSTRACT

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins. More... »

PAGES

32-43

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrm1548

DOI

http://dx.doi.org/10.1038/nrm1548

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019859884

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15688065


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