2004-06
AUTHORSRaphael Kopan, Ma. Xenia G. Ilagan
ABSTRACTγ-Secretase — a protease that cleaves within the membrane — was first recognized for its role in the production of amyloidogenic Aβ peptides, but was subsequently found to mediate Notch signalling by releasing the Notch-receptor intracellular domain. Many other γ-secretase substrates have recently been identified, which indicates a broader biological function for this unusual protease. Emerging evidence implies that whereas some intracellular cleavage products of γ-secretase function as signalling molecules, others might simply be intermediates that are destined for degradation. More... »
PAGES499-504
http://scigraph.springernature.com/pub.10.1038/nrm1406
DOIhttp://dx.doi.org/10.1038/nrm1406
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15173829
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