γ-Secretase: proteasome of the membrane? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Raphael Kopan, Ma. Xenia G. Ilagan

ABSTRACT

γ-Secretase — a protease that cleaves within the membrane — was first recognized for its role in the production of amyloidogenic Aβ peptides, but was subsequently found to mediate Notch signalling by releasing the Notch-receptor intracellular domain. Many other γ-secretase substrates have recently been identified, which indicates a broader biological function for this unusual protease. Emerging evidence implies that whereas some intracellular cleavage products of γ-secretase function as signalling molecules, others might simply be intermediates that are destined for degradation. More... »

PAGES

499-504

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrm1406

DOI

http://dx.doi.org/10.1038/nrm1406

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005035720

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15173829


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