Calcium: Regulation of cell death: the calcium–apoptosis link View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07

AUTHORS

Sten Orrenius, Boris Zhivotovsky, Pierluigi Nicotera

ABSTRACT

To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms--survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death. More... »

PAGES

552-565

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrm1150

DOI

http://dx.doi.org/10.1038/nrm1150

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044907943

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12838338


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