Piezos thrive under pressure: mechanically activated ion channels in health and disease View Full Text


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Article Info

DATE

2017-10-04

AUTHORS

Swetha E. Murthy, Adrienne E. Dubin, Ardem Patapoutian

ABSTRACT

Key PointsPiezos are bona fide mechanically activated ion channels that have a leading role in several cellular mechanotransduction events.Piezo proteins are unique in their size and lack homology to other membrane proteins. However, recent structural and functional studies have started to unravel architectural features of the channel.Piezo ion channels are activated by various physiologically relevant physical forces.The Piezo1 channel is involved in cardiovascular mechanotransduction, red blood cell volume regulation and epithelial homeostasis, and the Piezo2 channel is involved in sensory and respiratory mechanotransduction.Several genetic disorders linked to mutations in PIEZO1 and PIEZO2 have helped to uncover unexpected roles for mechanotransduction in mammalian physiology. More... »

PAGES

771-783

References to SciGraph publications

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  • Identifiers

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    DOI

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    49 schema:description Key PointsPiezos are bona fide mechanically activated ion channels that have a leading role in several cellular mechanotransduction events.Piezo proteins are unique in their size and lack homology to other membrane proteins. However, recent structural and functional studies have started to unravel architectural features of the channel.Piezo ion channels are activated by various physiologically relevant physical forces.The Piezo1 channel is involved in cardiovascular mechanotransduction, red blood cell volume regulation and epithelial homeostasis, and the Piezo2 channel is involved in sensory and respiratory mechanotransduction.Several genetic disorders linked to mutations in PIEZO1 and PIEZO2 have helped to uncover unexpected roles for mechanotransduction in mammalian physiology.
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