γδ T cells: functional plasticity and heterogeneity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-05

AUTHORS

Simon R Carding, Paul J Egan

ABSTRACT

Gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their biological function(s) remains unclear. On the basis of studies of gammadelta T cells in infectious and autoimmune diseases, we argue that gammadelta T cells perform different functions according to their tissue distribution, antigen-receptor structure and local microenvironment; we also discuss how and at what stage of the immune response they become activated. More... »

PAGES

336-345

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri797

DOI

http://dx.doi.org/10.1038/nri797

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051521787

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12033739


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