Spinning molecular immunology into successful immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

Drew M Pardoll

ABSTRACT

Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade. More... »

PAGES

227-238

References to SciGraph publications

  • 1992-11. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells in NATURE
  • 1998-03. Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells in NATURE MEDICINE
  • 2000-01. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b in NATURE
  • 1993-04. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma in NATURE
  • 2001-03. PD-L2 is a second ligand for PD-1 and inhibits T cell activation in NATURE IMMUNOLOGY
  • 1984-10. Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation in NATURE
  • 1995-12. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity in NATURE MEDICINE
  • 2001-08. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance in NATURE MEDICINE
  • 1997-05. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells in NATURE MEDICINE
  • 2002-03. Roles of heat-shock proteins in innate and adaptive immunity in NATURE REVIEWS IMMUNOLOGY
  • 1997-08. Developmental regulation of MHC class II transport in mouse dendritic cells in NATURE
  • 2000-04. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine in NATURE MEDICINE
  • 1997-08. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells in NATURE
  • 1997-07. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes in NATURE BIOTECHNOLOGY
  • 1995-05. A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours in NATURE MEDICINE
  • 1998-03. Dendritic cells and the control of immunity in NATURE
  • 1970-12. Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx in NATURE
  • 1999-12. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion in NATURE MEDICINE
  • 2001-01. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling in NATURE
  • 1997-06. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors in NATURE MEDICINE
  • 1998-03. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction in NATURE
  • 1996-01. Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells in NATURE MEDICINE
  • 2000-01. Cbl-b regulates the CD28 dependence of T-cell activation in NATURE
  • 1998-05. B cells inhibit induction of T cell-dependent tumor immunity in NATURE MEDICINE
  • 1999. Bacterial Mucosal Vaccines: Vibrio cholerae as a Live Attenuated Vaccine/Vector Paradigm in DEFENSE OF MUCOSAL SURFACES: PATHOGENESIS, IMMUNITY AND VACCINES
  • 2001-08. Toll-like receptors: critical proteins linking innate and acquired immunity in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri774

    DOI

    http://dx.doi.org/10.1038/nri774

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045044815

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12001994


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigen-Presenting Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cancer Vaccines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Vectors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. dmpardol@jhmi.edu"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pardoll", 
            "givenName": "Drew M", 
            "id": "sg:person.012740423777.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1084/jem.190.1.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000713236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910560108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001264753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910560108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001264753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.177.2.265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002090196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1295-1297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003113140", 
              "https://doi.org/10.1038/nm1295-1297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.2.747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003146420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(05)80059-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003709337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.1556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004369354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/70932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005008226", 
              "https://doi.org/10.1038/70932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.09.040191.001415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005122639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005563195", 
              "https://doi.org/10.1038/35003228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005563195", 
              "https://doi.org/10.1038/35003228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/362755a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005825416", 
              "https://doi.org/10.1038/362755a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006531015", 
              "https://doi.org/10.1038/32932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006531015", 
              "https://doi.org/10.1038/32932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.4.1486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006647224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00052-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006801851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.25.11810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006947674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(81)90585-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008074213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(81)90585-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008074213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/360258a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009029259", 
              "https://doi.org/10.1038/360258a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/42030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009213204", 
              "https://doi.org/10.1038/42030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/42030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009213204", 
              "https://doi.org/10.1038/42030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.175.5.1157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009715945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.183.1.317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010430085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.23.7155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010911330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910580409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011853789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0697-682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012086853", 
              "https://doi.org/10.1038/nm0697-682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199601000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013291883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199601000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013291883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.3.1178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014211724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014254484", 
              "https://doi.org/10.1038/35003235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014254484", 
              "https://doi.org/10.1038/35003235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.12.2357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014594252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0264-410x(96)00195-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015990963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.17.10067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016631953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.191.10.1699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016937459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80465-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017032008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.21.11341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017709590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0398-328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017994921", 
              "https://doi.org/10.1038/nm0398-328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.25.11671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018297652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.8.1213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018316567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(00)00239-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018568059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v97.1.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018641027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200105000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018660224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200105000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018660224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198110293051807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018983873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0797-641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019133624", 
              "https://doi.org/10.1038/nbt0797-641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80575-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020769294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(96)80078-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020892936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023226465", 
              "https://doi.org/10.1038/35053086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023226465", 
              "https://doi.org/10.1038/35053086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.2.465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023465729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024200162", 
              "https://doi.org/10.1038/nri749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024200162", 
              "https://doi.org/10.1038/nri749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0264-410x(01)00155-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024205062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/smim.2000.0220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026360706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/90942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026381384", 
              "https://doi.org/10.1038/90942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(97)80049-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026529736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028349667", 
              "https://doi.org/10.1038/74697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028349667", 
              "https://doi.org/10.1038/74697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(96)00078-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028444713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028604363", 
              "https://doi.org/10.1038/85330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028604363", 
              "https://doi.org/10.1038/85330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910460509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028967942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0597-558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029711419", 
              "https://doi.org/10.1038/nm0597-558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.8.1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030483244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.6.2982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030545465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0163-7258(98)00033-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032197404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.9.1553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032217862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.179.4.1109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032628043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/42039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032667892", 
              "https://doi.org/10.1038/42039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/42039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032667892", 
              "https://doi.org/10.1038/42039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.7.839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033089077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/89.21.1595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033132508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830261119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033218639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-5699(00)01612-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033579645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.22.13141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034584852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0595-471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036261702", 
              "https://doi.org/10.1038/nm0595-471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-59951-4_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037576125", 
              "https://doi.org/10.1007/978-3-642-59951-4_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-59951-4_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037576125", 
              "https://doi.org/10.1007/978-3-642-59951-4_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/311750a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037848804", 
              "https://doi.org/10.1038/311750a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0196-52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037938818", 
              "https://doi.org/10.1038/nm0196-52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200105)31:5<1602::aid-immu1602>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037968352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.133.6.1171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039028501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0264-410x(01)00233-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039117860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90409-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040120250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.20.10972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040312455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/90609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041087790", 
              "https://doi.org/10.1038/90609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/90609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041087790", 
              "https://doi.org/10.1038/90609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0598-627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041135508", 
              "https://doi.org/10.1038/nm0598-627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0598-627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041135508", 
              "https://doi.org/10.1038/nm0598-627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910510308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041930601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.191.11.1957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043336969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.5.1953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043544713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.19.1.565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043591484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.180.4.1263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043653729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044182901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1995.tb26649.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044364170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.5.645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044924423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.4.497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045112053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2281056a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045736096", 
              "https://doi.org/10.1038/2281056a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.182.3.885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045838179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.183.3.769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045903193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.3.355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046049906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.182.1.255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046852226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.8.3539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047468173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.2.229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047892315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048341608", 
              "https://doi.org/10.1038/32588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048341608", 
              "https://doi.org/10.1038/32588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(96)00079-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048416593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-4310(99)01633-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049504171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.151.3.673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049588409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.17.5364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049710518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.24.13146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050416767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(01)00111-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050501242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.7.1027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050568666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198902233200806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050582946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/10430349950016474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1840703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062509891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.270.5234.299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062551445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5335.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062558154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7545313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062647506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7652577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7678351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074270040", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.7.2105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074549817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.164.4.2160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074584657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074601062", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074640242", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2000.18.23.3894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074733877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.166.1.490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074740017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2001.19.1.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074743437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074783660", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074795178", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.166.9.5733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074802047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074805959", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074805961", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074805962", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.70.3.348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074871900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074949029", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078339195", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078397342", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1989.tb08594.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079024711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081606715", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081665522", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082511848", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082693295", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082854625", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jlb.59.2.208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082876980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082960813", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083072551", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083073974", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083164286", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-04", 
        "datePublishedReg": "2002-04-01", 
        "description": "Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nri774", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1029717", 
            "issn": [
              "1474-1733", 
              "1474-1741"
            ], 
            "name": "Nature Reviews Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Spinning molecular immunology into successful immunotherapy", 
        "pagination": "227-238", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d6902249a114e9916ca92a7d0a6bc8e70bcf7bbd2696f17733278a60772dd661"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12001994"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101124169"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nri774"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1045044815"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nri774", 
          "https://app.dimensions.ai/details/publication/pub.1045044815"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29200_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nri/journal/v2/n4/full/nri774.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nri774'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nri774'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nri774'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nri774'


     

    This table displays all metadata directly associated to this object as RDF triples.

    518 TRIPLES      21 PREDICATES      174 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nri774 schema:about N1ab55f89f51a42cea0c13fd11daf8a3a
    2 N703b084f69474ad49b0805b8b77fcf11
    3 N892cb897ce6947cc84e2b3283bd2e842
    4 N894221d8451b46c38d6e12726223f3f7
    5 Nc0f86a6c6cfc46a1a6cdd9dd77e92df4
    6 Nd8210c6ac98a452fa6b04c96ef58f7fb
    7 Ndb255ca5d6c8436aa7e14ea085921a89
    8 Nf5514ac8b2d2432dbfae2939e0a51499
    9 anzsrc-for:11
    10 anzsrc-for:1107
    11 schema:author N9079f8f0a40e413988bca673361ba6c5
    12 schema:citation sg:pub.10.1007/978-3-642-59951-4_12
    13 sg:pub.10.1038/2281056a0
    14 sg:pub.10.1038/311750a0
    15 sg:pub.10.1038/32588
    16 sg:pub.10.1038/32932
    17 sg:pub.10.1038/35003228
    18 sg:pub.10.1038/35003235
    19 sg:pub.10.1038/35053086
    20 sg:pub.10.1038/360258a0
    21 sg:pub.10.1038/362755a0
    22 sg:pub.10.1038/42030
    23 sg:pub.10.1038/42039
    24 sg:pub.10.1038/70932
    25 sg:pub.10.1038/74697
    26 sg:pub.10.1038/85330
    27 sg:pub.10.1038/90609
    28 sg:pub.10.1038/90942
    29 sg:pub.10.1038/nbt0797-641
    30 sg:pub.10.1038/nm0196-52
    31 sg:pub.10.1038/nm0398-328
    32 sg:pub.10.1038/nm0595-471
    33 sg:pub.10.1038/nm0597-558
    34 sg:pub.10.1038/nm0598-627
    35 sg:pub.10.1038/nm0697-682
    36 sg:pub.10.1038/nm1295-1297
    37 sg:pub.10.1038/nri749
    38 https://app.dimensions.ai/details/publication/pub.1074270040
    39 https://app.dimensions.ai/details/publication/pub.1074601062
    40 https://app.dimensions.ai/details/publication/pub.1074640242
    41 https://app.dimensions.ai/details/publication/pub.1074783660
    42 https://app.dimensions.ai/details/publication/pub.1074795178
    43 https://app.dimensions.ai/details/publication/pub.1074805959
    44 https://app.dimensions.ai/details/publication/pub.1074805961
    45 https://app.dimensions.ai/details/publication/pub.1074805962
    46 https://app.dimensions.ai/details/publication/pub.1074949029
    47 https://app.dimensions.ai/details/publication/pub.1078339195
    48 https://app.dimensions.ai/details/publication/pub.1078397342
    49 https://app.dimensions.ai/details/publication/pub.1081606715
    50 https://app.dimensions.ai/details/publication/pub.1081665522
    51 https://app.dimensions.ai/details/publication/pub.1082511848
    52 https://app.dimensions.ai/details/publication/pub.1082693295
    53 https://app.dimensions.ai/details/publication/pub.1082854625
    54 https://app.dimensions.ai/details/publication/pub.1082960813
    55 https://app.dimensions.ai/details/publication/pub.1083072551
    56 https://app.dimensions.ai/details/publication/pub.1083073974
    57 https://app.dimensions.ai/details/publication/pub.1083164286
    58 https://doi.org/10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n
    59 https://doi.org/10.1002/1521-4141(200105)31:5<1602::aid-immu1602>3.0.co;2-w
    60 https://doi.org/10.1002/eji.1830261119
    61 https://doi.org/10.1002/ijc.1556
    62 https://doi.org/10.1002/ijc.2910460509
    63 https://doi.org/10.1002/ijc.2910510308
    64 https://doi.org/10.1002/ijc.2910560108
    65 https://doi.org/10.1002/ijc.2910580409
    66 https://doi.org/10.1002/j.1460-2075.1989.tb08594.x
    67 https://doi.org/10.1002/jlb.59.2.208
    68 https://doi.org/10.1006/smim.2000.0220
    69 https://doi.org/10.1016/0022-1759(96)00078-6
    70 https://doi.org/10.1016/0022-1759(96)00079-8
    71 https://doi.org/10.1016/0092-8674(90)90409-8
    72 https://doi.org/10.1016/s0092-8674(00)80465-1
    73 https://doi.org/10.1016/s0092-8674(05)80059-5
    74 https://doi.org/10.1016/s0140-6736(81)90585-7
    75 https://doi.org/10.1016/s0163-7258(98)00033-3
    76 https://doi.org/10.1016/s0167-5699(00)01612-1
    77 https://doi.org/10.1016/s0264-410x(01)00155-4
    78 https://doi.org/10.1016/s0264-410x(01)00233-x
    79 https://doi.org/10.1016/s0264-410x(96)00195-8
    80 https://doi.org/10.1016/s0952-7915(00)00239-9
    81 https://doi.org/10.1016/s0952-7915(96)80078-1
    82 https://doi.org/10.1016/s0952-7915(97)80049-0
    83 https://doi.org/10.1016/s1074-7613(00)00052-2
    84 https://doi.org/10.1016/s1074-7613(00)80575-0
    85 https://doi.org/10.1016/s1074-7613(01)00111-x
    86 https://doi.org/10.1016/s1357-4310(99)01633-0
    87 https://doi.org/10.1056/nejm198110293051807
    88 https://doi.org/10.1056/nejm198902233200806
    89 https://doi.org/10.1073/pnas.80.17.5364
    90 https://doi.org/10.1073/pnas.80.23.7155
    91 https://doi.org/10.1073/pnas.87.4.1486
    92 https://doi.org/10.1073/pnas.90.8.3539
    93 https://doi.org/10.1073/pnas.92.25.11671
    94 https://doi.org/10.1073/pnas.92.25.11810
    95 https://doi.org/10.1073/pnas.93.20.10972
    96 https://doi.org/10.1073/pnas.93.21.11341
    97 https://doi.org/10.1073/pnas.94.24.13146
    98 https://doi.org/10.1073/pnas.95.17.10067
    99 https://doi.org/10.1073/pnas.95.22.13141
    100 https://doi.org/10.1073/pnas.95.3.1178
    101 https://doi.org/10.1073/pnas.96.6.2982
    102 https://doi.org/10.1083/jcb.151.3.673
    103 https://doi.org/10.1084/jem.133.6.1171
    104 https://doi.org/10.1084/jem.175.5.1157
    105 https://doi.org/10.1084/jem.177.2.265
    106 https://doi.org/10.1084/jem.179.4.1109
    107 https://doi.org/10.1084/jem.180.4.1263
    108 https://doi.org/10.1084/jem.182.1.255
    109 https://doi.org/10.1084/jem.182.3.885
    110 https://doi.org/10.1084/jem.183.1.317
    111 https://doi.org/10.1084/jem.183.3.769
    112 https://doi.org/10.1084/jem.184.2.465
    113 https://doi.org/10.1084/jem.184.2.747
    114 https://doi.org/10.1084/jem.184.5.1953
    115 https://doi.org/10.1084/jem.186.2.229
    116 https://doi.org/10.1084/jem.186.5.645
    117 https://doi.org/10.1084/jem.186.8.1213
    118 https://doi.org/10.1084/jem.186.8.1247
    119 https://doi.org/10.1084/jem.188.12.2357
    120 https://doi.org/10.1084/jem.188.9.1553
    121 https://doi.org/10.1084/jem.190.1.125
    122 https://doi.org/10.1084/jem.190.3.355
    123 https://doi.org/10.1084/jem.191.10.1699
    124 https://doi.org/10.1084/jem.191.11.1957
    125 https://doi.org/10.1084/jem.192.7.1027
    126 https://doi.org/10.1084/jem.193.4.497
    127 https://doi.org/10.1084/jem.193.7.839
    128 https://doi.org/10.1089/10430349950016474
    129 https://doi.org/10.1093/jnci/89.21.1595
    130 https://doi.org/10.1097/00002371-199601000-00009
    131 https://doi.org/10.1097/00002371-200105000-00006
    132 https://doi.org/10.1111/j.1749-6632.1995.tb26649.x
    133 https://doi.org/10.1126/science.1840703
    134 https://doi.org/10.1126/science.270.5234.299
    135 https://doi.org/10.1126/science.278.5335.117
    136 https://doi.org/10.1126/science.7545313
    137 https://doi.org/10.1126/science.7652577
    138 https://doi.org/10.1126/science.7678351
    139 https://doi.org/10.1146/annurev.immunol.19.1.565
    140 https://doi.org/10.1146/annurev.iy.09.040191.001415
    141 https://doi.org/10.1182/blood.v97.1.114
    142 https://doi.org/10.1189/jlb.70.3.348
    143 https://doi.org/10.1200/jco.1999.17.7.2105
    144 https://doi.org/10.1200/jco.2000.18.23.3894
    145 https://doi.org/10.1200/jco.2001.19.1.145
    146 https://doi.org/10.4049/jimmunol.164.4.2160
    147 https://doi.org/10.4049/jimmunol.166.1.490
    148 https://doi.org/10.4049/jimmunol.166.9.5733
    149 schema:datePublished 2002-04
    150 schema:datePublishedReg 2002-04-01
    151 schema:description Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade.
    152 schema:genre research_article
    153 schema:inLanguage en
    154 schema:isAccessibleForFree false
    155 schema:isPartOf N48530103bf624d7b99f6a79bfb5af173
    156 N98679dc06aba4bac95346f3cf8ce0968
    157 sg:journal.1029717
    158 schema:name Spinning molecular immunology into successful immunotherapy
    159 schema:pagination 227-238
    160 schema:productId N0dbc642512c94152974bdaa762ed3a7c
    161 N0df64a1d07f6419b8bc2c4993adfa07c
    162 N32f650cca403412c92d430418ff53d1a
    163 N540d0d3a52ba4cd29ba90a13fb5f46a8
    164 N654c693c866244739179ae1425928298
    165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045044815
    166 https://doi.org/10.1038/nri774
    167 schema:sdDatePublished 2019-04-11T11:54
    168 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    169 schema:sdPublisher Ne9737f3b476c4ff1b7e8d9c3af86b4a4
    170 schema:url http://www.nature.com/nri/journal/v2/n4/full/nri774.html
    171 sgo:license sg:explorer/license/
    172 sgo:sdDataset articles
    173 rdf:type schema:ScholarlyArticle
    174 N0dbc642512c94152974bdaa762ed3a7c schema:name doi
    175 schema:value 10.1038/nri774
    176 rdf:type schema:PropertyValue
    177 N0df64a1d07f6419b8bc2c4993adfa07c schema:name pubmed_id
    178 schema:value 12001994
    179 rdf:type schema:PropertyValue
    180 N1ab55f89f51a42cea0c13fd11daf8a3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name T-Lymphocytes
    182 rdf:type schema:DefinedTerm
    183 N32f650cca403412c92d430418ff53d1a schema:name readcube_id
    184 schema:value d6902249a114e9916ca92a7d0a6bc8e70bcf7bbd2696f17733278a60772dd661
    185 rdf:type schema:PropertyValue
    186 N48530103bf624d7b99f6a79bfb5af173 schema:issueNumber 4
    187 rdf:type schema:PublicationIssue
    188 N540d0d3a52ba4cd29ba90a13fb5f46a8 schema:name nlm_unique_id
    189 schema:value 101124169
    190 rdf:type schema:PropertyValue
    191 N654c693c866244739179ae1425928298 schema:name dimensions_id
    192 schema:value pub.1045044815
    193 rdf:type schema:PropertyValue
    194 N703b084f69474ad49b0805b8b77fcf11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Genetic Vectors
    196 rdf:type schema:DefinedTerm
    197 N892cb897ce6947cc84e2b3283bd2e842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Humans
    199 rdf:type schema:DefinedTerm
    200 N894221d8451b46c38d6e12726223f3f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Immunotherapy
    202 rdf:type schema:DefinedTerm
    203 N9079f8f0a40e413988bca673361ba6c5 rdf:first sg:person.012740423777.12
    204 rdf:rest rdf:nil
    205 N98679dc06aba4bac95346f3cf8ce0968 schema:volumeNumber 2
    206 rdf:type schema:PublicationVolume
    207 Nc0f86a6c6cfc46a1a6cdd9dd77e92df4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Neoplasms
    209 rdf:type schema:DefinedTerm
    210 Nd8210c6ac98a452fa6b04c96ef58f7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Antigen-Presenting Cells
    212 rdf:type schema:DefinedTerm
    213 Ndb255ca5d6c8436aa7e14ea085921a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Cancer Vaccines
    215 rdf:type schema:DefinedTerm
    216 Ne9737f3b476c4ff1b7e8d9c3af86b4a4 schema:name Springer Nature - SN SciGraph project
    217 rdf:type schema:Organization
    218 Nf5514ac8b2d2432dbfae2939e0a51499 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Animals
    220 rdf:type schema:DefinedTerm
    221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Medical and Health Sciences
    223 rdf:type schema:DefinedTerm
    224 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Immunology
    226 rdf:type schema:DefinedTerm
    227 sg:journal.1029717 schema:issn 1474-1733
    228 1474-1741
    229 schema:name Nature Reviews Immunology
    230 rdf:type schema:Periodical
    231 sg:person.012740423777.12 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    232 schema:familyName Pardoll
    233 schema:givenName Drew M
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12
    235 rdf:type schema:Person
    236 sg:pub.10.1007/978-3-642-59951-4_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037576125
    237 https://doi.org/10.1007/978-3-642-59951-4_12
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/2281056a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045736096
    240 https://doi.org/10.1038/2281056a0
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/311750a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037848804
    243 https://doi.org/10.1038/311750a0
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/32588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048341608
    246 https://doi.org/10.1038/32588
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/32932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006531015
    249 https://doi.org/10.1038/32932
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/35003228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005563195
    252 https://doi.org/10.1038/35003228
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/35003235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014254484
    255 https://doi.org/10.1038/35003235
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/35053086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023226465
    258 https://doi.org/10.1038/35053086
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/360258a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009029259
    261 https://doi.org/10.1038/360258a0
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/362755a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005825416
    264 https://doi.org/10.1038/362755a0
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/42030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009213204
    267 https://doi.org/10.1038/42030
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/42039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032667892
    270 https://doi.org/10.1038/42039
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/70932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005008226
    273 https://doi.org/10.1038/70932
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/74697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028349667
    276 https://doi.org/10.1038/74697
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/85330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028604363
    279 https://doi.org/10.1038/85330
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/90609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041087790
    282 https://doi.org/10.1038/90609
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/90942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026381384
    285 https://doi.org/10.1038/90942
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nbt0797-641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019133624
    288 https://doi.org/10.1038/nbt0797-641
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nm0196-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037938818
    291 https://doi.org/10.1038/nm0196-52
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nm0398-328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017994921
    294 https://doi.org/10.1038/nm0398-328
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nm0595-471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036261702
    297 https://doi.org/10.1038/nm0595-471
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nm0597-558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029711419
    300 https://doi.org/10.1038/nm0597-558
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nm0598-627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041135508
    303 https://doi.org/10.1038/nm0598-627
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nm0697-682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012086853
    306 https://doi.org/10.1038/nm0697-682
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nm1295-1297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003113140
    309 https://doi.org/10.1038/nm1295-1297
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nri749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024200162
    312 https://doi.org/10.1038/nri749
    313 rdf:type schema:CreativeWork
    314 https://app.dimensions.ai/details/publication/pub.1074270040 schema:CreativeWork
    315 https://app.dimensions.ai/details/publication/pub.1074601062 schema:CreativeWork
    316 https://app.dimensions.ai/details/publication/pub.1074640242 schema:CreativeWork
    317 https://app.dimensions.ai/details/publication/pub.1074783660 schema:CreativeWork
    318 https://app.dimensions.ai/details/publication/pub.1074795178 schema:CreativeWork
    319 https://app.dimensions.ai/details/publication/pub.1074805959 schema:CreativeWork
    320 https://app.dimensions.ai/details/publication/pub.1074805961 schema:CreativeWork
    321 https://app.dimensions.ai/details/publication/pub.1074805962 schema:CreativeWork
    322 https://app.dimensions.ai/details/publication/pub.1074949029 schema:CreativeWork
    323 https://app.dimensions.ai/details/publication/pub.1078339195 schema:CreativeWork
    324 https://app.dimensions.ai/details/publication/pub.1078397342 schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1081606715 schema:CreativeWork
    326 https://app.dimensions.ai/details/publication/pub.1081665522 schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1082511848 schema:CreativeWork
    328 https://app.dimensions.ai/details/publication/pub.1082693295 schema:CreativeWork
    329 https://app.dimensions.ai/details/publication/pub.1082854625 schema:CreativeWork
    330 https://app.dimensions.ai/details/publication/pub.1082960813 schema:CreativeWork
    331 https://app.dimensions.ai/details/publication/pub.1083072551 schema:CreativeWork
    332 https://app.dimensions.ai/details/publication/pub.1083073974 schema:CreativeWork
    333 https://app.dimensions.ai/details/publication/pub.1083164286 schema:CreativeWork
    334 https://doi.org/10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1044182901
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1002/1521-4141(200105)31:5<1602::aid-immu1602>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1037968352
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1002/eji.1830261119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033218639
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1002/ijc.1556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004369354
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1002/ijc.2910460509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028967942
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1002/ijc.2910510308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041930601
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1002/ijc.2910560108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001264753
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1002/ijc.2910580409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853789
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1002/j.1460-2075.1989.tb08594.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079024711
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1002/jlb.59.2.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082876980
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1006/smim.2000.0220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026360706
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/0022-1759(96)00078-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028444713
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/0022-1759(96)00079-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048416593
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/0092-8674(90)90409-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040120250
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/s0092-8674(00)80465-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017032008
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/s0092-8674(05)80059-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003709337
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/s0140-6736(81)90585-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008074213
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/s0163-7258(98)00033-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032197404
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/s0167-5699(00)01612-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033579645
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/s0264-410x(01)00155-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024205062
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/s0264-410x(01)00233-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039117860
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/s0264-410x(96)00195-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015990963
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/s0952-7915(00)00239-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018568059
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/s0952-7915(96)80078-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020892936
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/s0952-7915(97)80049-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026529736
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/s1074-7613(00)00052-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006801851
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/s1074-7613(00)80575-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020769294
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/s1074-7613(01)00111-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050501242
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/s1357-4310(99)01633-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049504171
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1056/nejm198110293051807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018983873
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1056/nejm198902233200806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050582946
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1073/pnas.80.17.5364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049710518
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1073/pnas.80.23.7155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010911330
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1073/pnas.87.4.1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006647224
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1073/pnas.90.8.3539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047468173
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1073/pnas.92.25.11671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018297652
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1073/pnas.92.25.11810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006947674
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1073/pnas.93.20.10972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040312455
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1073/pnas.93.21.11341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017709590
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1073/pnas.94.24.13146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050416767
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1073/pnas.95.17.10067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016631953
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1073/pnas.95.22.13141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034584852
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1073/pnas.95.3.1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014211724
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1073/pnas.96.6.2982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030545465
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1083/jcb.151.3.673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049588409
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1084/jem.133.6.1171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039028501
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1084/jem.175.5.1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009715945
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1084/jem.177.2.265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002090196
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1084/jem.179.4.1109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032628043
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1084/jem.180.4.1263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043653729
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1084/jem.182.1.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046852226
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1084/jem.182.3.885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045838179
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1084/jem.183.1.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010430085
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1084/jem.183.3.769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045903193
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1084/jem.184.2.465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023465729
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1084/jem.184.2.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003146420
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1084/jem.184.5.1953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043544713
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1084/jem.186.2.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047892315
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1084/jem.186.5.645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044924423
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1084/jem.186.8.1213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018316567
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1084/jem.186.8.1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030483244
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1084/jem.188.12.2357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014594252
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1084/jem.188.9.1553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032217862
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1084/jem.190.1.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000713236
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1084/jem.190.3.355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046049906
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1084/jem.191.10.1699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016937459
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1084/jem.191.11.1957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043336969
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1084/jem.192.7.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050568666
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1084/jem.193.4.497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045112053
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1084/jem.193.7.839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033089077
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1089/10430349950016474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202794
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1093/jnci/89.21.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033132508
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1097/00002371-199601000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013291883
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1097/00002371-200105000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018660224
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1111/j.1749-6632.1995.tb26649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044364170
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1126/science.1840703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062509891
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1126/science.270.5234.299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551445
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1126/science.278.5335.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558154
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1126/science.7545313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647506
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1126/science.7652577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648309
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1126/science.7678351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648365
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1146/annurev.immunol.19.1.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043591484
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1146/annurev.iy.09.040191.001415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005122639
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1182/blood.v97.1.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018641027
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1189/jlb.70.3.348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074871900
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1200/jco.1999.17.7.2105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549817
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1200/jco.2000.18.23.3894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074733877
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1200/jco.2001.19.1.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074743437
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.4049/jimmunol.164.4.2160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074584657
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.4049/jimmunol.166.1.490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074740017
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.4049/jimmunol.166.9.5733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074802047
    515 rdf:type schema:CreativeWork
    516 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    517 schema:name Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. dmpardol@jhmi.edu
    518 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...