The B7–CD28 superfamily View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Arlene H. Sharpe, Gordon J. Freeman

ABSTRACT

The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells. Several B7 homologues are expressed on cells other than professional antigen-presenting cells, indicating new mechanisms for regulating T-cell responses in peripheral tissues. Some B7 homologues have unknown receptors, indicating that other immunoregulatory pathways remain to be described. Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential. More... »

PAGES

116-126

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Immunology

    ISSUE

    2

    VOLUME

    2

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri727

    DOI

    http://dx.doi.org/10.1038/nri727

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007286982

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11910893


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