C-type lectin receptors on dendritic cells and langerhans cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Carl G. Figdor, Yvette van Kooyk, Gosse J. Adema

ABSTRACT

Key Points Dendritic cells (DCs) and Langerhans cells (LCs) are professional antigen-presenting cells that play a pivotal role in the initiation and modulation of immune responses. DCs and LCs are migratory cells that are specialized in antigen uptake and the processing and presentation of these antigens to lymphocytes. In addition to DCs and LCs, there are other DC subsets, such as the plasmacytoid DCs that secrete high amounts of type I interferons. Molecular profiling of DCs showed that they produce a unique set of C-type lectins and C-type lectin-like receptors. Different DC subsets and maturation stages exhibit distinct 'C-type-lectin' production profiles. C-type lectins bind carbohydrates in a Ca2+-dependent manner and C-type lectin-like molecules bind either carbohydrates, polypeptide ligands or both. C-type lectins and C-type lectin-like receptors are involved in a multitude of biological processes, including cell migration, antigen uptake and presentation and cell adhesion. Recently, it has been shown that the C-type lectins Langerin and DC-SIGN are preferentially produced by DCs. Langerin is a constituent of the enigmatic Birbeck granules found in LCs. DC-SIGN is a high-affinity receptor for ICAM-3, which is abundantly expressed on naive T cells and has been implicated in the well-known phenomenon of antigen-independent DC–T-cell clustering. DC-SIGN has also been shown to bind HIV-1 through interaction with the coat protein gp120 and to promote efficient infection in trans of T cells that produce the classical HIV CD4 and chemokine receptors. More... »

PAGES

77-84

Journal

TITLE

Nature Reviews Immunology

ISSUE

2

VOLUME

2

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri723

    DOI

    http://dx.doi.org/10.1038/nri723

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041081450

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11910898


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