The enemy within: keeping self-reactive T cells at bay in the periphery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-01

AUTHORS

Lucy S K Walker, Abul K Abbas

ABSTRACT

The remarkable capacity of the mammalian immune system to coordinate deadly attacks against numerous invading pathogens, yet turn a blind eye to self-tissues continues to fascinate immunologists. It has been clear for some time that immune cells capable of recognizing self-proteins exist in normal individuals without seemingly causing harm. The 'peripheral tolerance' mechanisms that keep these cells in check are the focus of intense research, not least because defects in these pathways might cause autoimmune diseases. In this review, new developments in our understanding of peripheral tolerance are discussed. More... »

PAGES

11-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri701

DOI

http://dx.doi.org/10.1038/nri701

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020255566

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11908514


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