The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

David Klatzmann, Abul K. Abbas

ABSTRACT

Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ autoimmune disease and inflammation. This indicates that in a normal immune system, there are self-specific effector T cells that are ready to attack normal tissue if they are not restrained by TReg cells. The data imply that there is a balance between effector T cells and TReg cells in health and suggest a therapeutic potential of TReg cells in diseases in which this balance is altered. Proof-of-concept clinical trials, now supported by robust mechanistic studies, have shown that low-dose interleukin-2 specifically expands and activates TReg cell populations and thus can control autoimmune diseases and inflammation. More... »

PAGES

283-294

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri3823

    DOI

    http://dx.doi.org/10.1038/nri3823

    DIMENSIONS

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    PUBMED

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