Integrating canonical and metabolic signalling programmes in the regulation of T cell responses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-07

AUTHORS

Kristen N. Pollizzi, Jonathan D. Powell

ABSTRACT

Over the past decade, our understanding of T cell activation, differentiation and function has markedly expanded, providing a greater appreciation of the signals and pathways that regulate these processes. It has become clear that evolutionarily conserved pathways that regulate stress responses, metabolism, autophagy and survival have crucial and specific roles in regulating T cell responses. Recent studies suggest that the metabolic pathways involving MYC, hypoxia-inducible factor 1α (HIF1α), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are activated upon antigen recognition and that they are required for directing the consequences of T cell receptor engagement. The purpose of this Review is to provide an integrated view of the role of these metabolic pathways and of canonical T cell signalling pathways in regulating the outcome of T cell responses. More... »

PAGES

435-446

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri3701

    DOI

    http://dx.doi.org/10.1038/nri3701

    DIMENSIONS

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    PUBMED

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