Towards a systems understanding of MHC class I and MHC class II antigen presentation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11-11

AUTHORS

Jacques Neefjes, Marlieke L. M. Jongsma, Petra Paul, Oddmund Bakke

ABSTRACT

Key PointsMHC class I and MHC class II molecules have long been intensively studied, and this has resulted in a global view of these processes. New technologies, including genome-wide small interfering RNA screens and systems biology approaches, have identified numerous additional pathways that control antigen presentation by MHC molecules.MHC molecules are polymorphic, and the biology of the various alleles differs, such that they can potentially have different consequences with regards to the relevant immune responses. This point is best-defined for MHC class I molecules. In this Review, we bring this into context with the current understanding of the general MHC class I antigen presentation process.The biology of MHC molecules touches almost all areas in the field of cell biology. Various new findings from the area of cell biology have consequences for MHC class I and MHC class II antigen presentation.The immune system is a relatively late addition in our progress through evolution, and many immune-specific molecules exist. Unique functions of some of these, including the immunoproteasome in interferon-induced damage clearance, have been recently uncovered.Through a combination of small interfering RNA screens, microarrays and cell biological approaches, novel pathways that control MHC class II expression and transport in dendritic cells have been defined. The systems biology of MHC molecules will yield more surprises.A dynamic field of research has many unsolved issues. A survey of the views of almost 50 group leaders in the field of antigen presentation has provided democratic opinions on the variety of unsettled topics within the field. More... »

PAGES

823-836

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  • Journal

    TITLE

    Nature Reviews Immunology

    ISSUE

    12

    VOLUME

    11

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri3084

    DOI

    http://dx.doi.org/10.1038/nri3084

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008129976

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22076556


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