Adipokines in inflammation and metabolic disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-02

AUTHORS

Noriyuki Ouchi, Jennifer L. Parker, Jesse J. Lugus, Kenneth Walsh

ABSTRACT

The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function. More... »

PAGES

85

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri2921

    DOI

    http://dx.doi.org/10.1038/nri2921

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031976538

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21252989


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