iNKT cell autoreactivity: what is 'self' and how is it recognized? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04

AUTHORS

Laurent Gapin

ABSTRACT

Following stimulation through their T cell receptor, invariant natural killer T (iNKT) cells function as innate effector cells by rapidly releasing large amounts of effector cytokines and chemokines and therefore have an important role in modulating the ensuing immune response. iNKT cells recognize, and are activated by, diverse glycolipid antigens, many of which are found in microorganisms. However, iNKT cells also show some reactivity to 'self'. Here, I outline our current understanding of iNKT cell autoreactivity and propose that several self lipids are probably involved in the positive selection and autoreactivity of iNKT cells. More... »

PAGES

272

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri2743

    DOI

    http://dx.doi.org/10.1038/nri2743

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008861964

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20224567


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