B-cell responses to vaccination at the extremes of age View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03

AUTHORS

Claire-Anne Siegrist, Richard Aspinall

ABSTRACT

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups. More... »

PAGES

185-194

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri2508

DOI

http://dx.doi.org/10.1038/nri2508

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010635263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19240757


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