The different faces of Notch in T-helper-cell differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-02

AUTHORS

Derk Amsen, Andrey Antov, Richard A. Flavell

ABSTRACT

Interleukin-12 (IL-12) and IL-4 induce T helper 1 (T(H)1)- and T(H)2-cell differentiation, respectively, in vitro. However, not all T(H)1-cell responses require IL-12 in vivo, and T(H)2-cell responses are remarkably independent of IL-4-receptor signalling, suggesting that other polarizing signals must exist. Accumulating evidence indicates that Notch is a candidate receptor that might mediate these signals. However, contrasting roles for Notch have been proposed: some evidence shows that Notch promotes T(H)1-cell differentiation, whereas other evidence supports a prominent role for Notch in T(H)2-cell differentiation. In this Review, we discuss recent findings that help to reconcile this discrepancy and highlight the accumulating evidence for the role of Notch in T-cell-mediated diseases. More... »

PAGES

116-124

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri2488

    DOI

    http://dx.doi.org/10.1038/nri2488

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016454220

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19165228


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