Harnessing invariant NKT cells in vaccination strategies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01

AUTHORS

Vincenzo Cerundolo, Jonathan D. Silk, S. Hajar Masri, Mariolina Salio

ABSTRACT

To optimize vaccination strategies, it is important to use protocols that can 'jump-start' immune responses by harnessing cells of the innate immune system to assist the expansion of antigen-specific B and T cells. In this Review, we discuss the evidence indicating that invariant natural killer T (iNKT) cells can positively modulate dendritic cells and B cells, and that their pharmacological activation in the presence of antigenic proteins can enhance antigen-specific B- and T-cell responses. In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants. More... »

PAGES

28-38

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri2451

    DOI

    http://dx.doi.org/10.1038/nri2451

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045290786

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19079136


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