Mesenchymal stem cells in health and disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-09

AUTHORS

Antonio Uccelli, Lorenzo Moretta, Vito Pistoia

ABSTRACT

Key PointsBone-marrow-derived multipotent progenitor stromal cells — or mesenchymal stem cells (MSCs) — are the common predecessors of cells of the mesenchymal lineage, such as bone, cartilage and fat cells. They can also differentiate into cells from unrelated germline lineages (a process known as transdifferentiation).Bone-marrow-derived stromal cells are the functional components of the haematopoietic stem cell (HSC) niche that support HSC homeostasis and they have anti-proliferative features that are in common with physiological stromal niches.MSCs regulate many effector functions of innate immune cells, such as antigen presentation by dendritic cells (DCs), natural killer (NK)-cell cytotoxicity and the activation of neutrophils. However, activated NK cells can also kill MSCs.MSCs inhibit T-cell proliferation through the induction of cell-division arrest, which is enhanced by interferon-γ released by activated T cells. MSCs also impair B-cell functions, such as antibody production.After in vivo intravenous administration, MSCs can induce T-cell peripheral tolerance, home to inflamed tissues and exert a potent tissue-protective effect through the release of anti-inflammatory, anti-apoptotic and trophic molecules. In vivo studies indicate that the therapeutic effect of MSCs occurring through cell replacement is limited.Clinical exploitation of in vitro-cultured MSCs has been safely carried out in some human conditions, which indicates that MSCs might be a new strategy for the treatment of immune-mediated diseases. More... »

PAGES

726-736

References to SciGraph publications

  • 2007-03-06. The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse in BMC GENOMICS
  • 2002-08-26. Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract in NATURE MEDICINE
  • 2001-04-05. Bone marrow cells regenerate infarcted myocardium in NATURE
  • 1999-03. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta in NATURE MEDICINE
  • 2002-12. Natural killer cells and dendritic cells: rendezvous in abused tissues in NATURE REVIEWS IMMUNOLOGY
  • 2007-10-04. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis in NATURE
  • 2008-03-07. Uncertainty in the niches that maintain haematopoietic stem cells in NATURE REVIEWS IMMUNOLOGY
  • 2001-05-01. The microenvironment of the tumour–host interface in NATURE
  • 2003-08-10. Bone marrow as a priming site for T-cell responses to blood-borne antigen in NATURE MEDICINE
  • 2006-05. The therapeutic potential of neural stem cells in NATURE REVIEWS NEUROSCIENCE
  • 2006-02. Bone-marrow haematopoietic-stem-cell niches in NATURE REVIEWS IMMUNOLOGY
  • 2006-12-14. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth in LEUKEMIA
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 2008-01-10. The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study in LEUKEMIA
  • 2005-10-03. Normal bone marrow hematopoietic stem cell reserves and normal stromal cell function support the use of autologous stem cell transplantation in patients with multiple sclerosis in BONE MARROW TRANSPLANTATION
  • 2006-11-09. Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma in LEUKEMIA
  • Journal

    TITLE

    Nature Reviews Immunology

    ISSUE

    9

    VOLUME

    8

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri2395

    DOI

    http://dx.doi.org/10.1038/nri2395

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034703692

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19172693


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