The molecular basis for public T-cell responses? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03

AUTHORS

Vanessa Venturi, David A. Price, Daniel C. Douek, Miles P. Davenport

ABSTRACT

Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are observed to dominate the response to the same antigenic epitope in multiple individuals, have long been a focus of immune T-cell repertoire studies. However, the mechanism that enables the survival of a specific TCR from the diverse repertoire produced in the thymus through to its involvement in a public immune response remains unclear. In this Opinion article, we propose that the frequency of production of T cells bearing different TCRs during recombination has an important role in the sharing of TCRs in an immune response, with variable levels of 'convergent recombination' driving production frequencies. More... »

PAGES

231-238

Journal

TITLE

Nature Reviews Immunology

ISSUE

3

VOLUME

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri2260

DOI

http://dx.doi.org/10.1038/nri2260

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050236486

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18301425


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