TH1 cells control themselves by producing interleukin-10 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Anne O'Garra, Paulo Vieira

ABSTRACT

Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection. More... »

PAGES

425-428

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri2097

DOI

http://dx.doi.org/10.1038/nri2097

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013715729

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17525751


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