Cooperation of Toll-like receptor signals in innate immune defence View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03

AUTHORS

Giorgio Trinchieri, Alan Sher

ABSTRACT

The mechanisms by which the recognition of Toll-like receptor (TLR) ligands leads to host immunity remain poorly defined. It is now thought that to induce an effective immune response, microorganisms must stimulate complex sets of pattern-recognition receptors, both within and outside of the TLR family. The combined activation of these different receptors can result in complementary, synergistic or antagonistic effects that modulate innate and adaptive immunity. Therefore, a complete understanding of the role of TLRs in host resistance to infection requires 'decoding' of these multiple receptor interactions. This Review highlights recent advances in the newly emerging field of TLR cooperation and discusses their implications for the development of adjuvants and immunotherapies. More... »

PAGES

179-190

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  • Journal

    TITLE

    Nature Reviews Immunology

    ISSUE

    3

    VOLUME

    7

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri2038

    DOI

    http://dx.doi.org/10.1038/nri2038

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011537546

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17318230


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