Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01

AUTHORS

Hua Yu, Marcin Kortylewski, Drew Pardoll

ABSTRACT

Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour immune response, but also interact intimately with the transformed cells to promote oncogenesis actively. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activated both in tumour cells and in immune cells in the tumour microenvironment. Constitutively activated STAT3 inhibits the expression of mediators necessary for immune activation against tumour cells. Furthermore, STAT3 activity promotes the production of immunosuppressive factors that activate STAT3 in diverse immune-cell subsets, altering gene-expression programmes and, thereby, restraining anti-tumour immune responses. As such, STAT3 propagates several levels of crosstalk between tumour cells and their immunological microenvironment, leading to tumour-induced immunosuppression. Consequently, STAT3 has emerged as a promising target for cancer immunotherapy. More... »

PAGES

41-51

Journal

TITLE

Nature Reviews Immunology

ISSUE

1

VOLUME

7

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri1995

    DOI

    http://dx.doi.org/10.1038/nri1995

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052092567

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17186030


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