Regulatory T cells, tumour immunity and immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Weiping Zou

ABSTRACT

Tumours express a range of antigens, including self-antigens. Regulatory T cells are crucial for maintaining T-cell tolerance to self-antigens. Regulatory T cells are thought to dampen T-cell immunity to tumour-associated antigens and to be the main obstacle tempering successful immunotherapy and active vaccination. In this Review, I consider the nature and characteristics of regulatory T cells in the tumour microenvironment and their potential multiple suppressive mechanisms. Strategies for therapeutic targeting of regulatory T cells and the effect of regulatory T cells on current immunotherapeutic and vaccine regimens are discussed. More... »

PAGES

295-307

References to SciGraph publications

Journal

TITLE

Nature Reviews Immunology

ISSUE

4

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri1806

DOI

http://dx.doi.org/10.1038/nri1806

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004289511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16557261


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