Ontology type: schema:ScholarlyArticle
2005-01
AUTHORSTomas Mustelin, Torkel Vang, Nunzio Bottini
ABSTRACTReversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases. Together, cells of the immune system express at least half of the 107 protein tyrosine phosphatase (PTP) genes in the human genome, most of which encode multidomain proteins that contain protein- and phospholipid-interaction domains. Here, we discuss the diverse but specific, and important, roles that PTPs have in immune cells, focusing mainly on T and B cells, and we highlight recent evidence that even subtle alterations in PTPs can cause immune dysfunction and human disease. More... »
PAGES43-57
http://scigraph.springernature.com/pub.10.1038/nri1530
DOIhttp://dx.doi.org/10.1038/nri1530
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1015952054
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15630428
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