Protein tyrosine phosphatases and the immune response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01

AUTHORS

Tomas Mustelin, Torkel Vang, Nunzio Bottini

ABSTRACT

Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases. Together, cells of the immune system express at least half of the 107 protein tyrosine phosphatase (PTP) genes in the human genome, most of which encode multidomain proteins that contain protein- and phospholipid-interaction domains. Here, we discuss the diverse but specific, and important, roles that PTPs have in immune cells, focusing mainly on T and B cells, and we highlight recent evidence that even subtle alterations in PTPs can cause immune dysfunction and human disease. More... »

PAGES

43-57

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri1530

    DOI

    http://dx.doi.org/10.1038/nri1530

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015952054

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15630428


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