Ido expression by dendritic cells: tolerance and tryptophan catabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-10

AUTHORS

Andrew L Mellor, David H Munn

ABSTRACT

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction. More... »

PAGES

762-774

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  • Journal

    TITLE

    Nature Reviews Immunology

    ISSUE

    10

    VOLUME

    4

    Author Affiliations

    Related Patents

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri1457

    DOI

    http://dx.doi.org/10.1038/nri1457

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006344136

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15459668


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