A forward-genetic approach for analysis of the immune system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-06

AUTHORS

Mark W Appleby, Fred Ramsdell

ABSTRACT

The completion of the genome sequences of both humans and mice challenges biologists to determine gene function on a vast, whole-organism scale. Both phenotype-based ('forward') and gene-based ('reverse') strategies are being developed to approach this issue. Forward-genetic approaches, however, provide the unique ability of assigning function to genes in an unbiased, global manner that is independent of previous assumptions about gene function. In this article, we compare various genetic technologies for their potential role in dissecting immune-system development and function, with particular emphasis on the worldwide efforts that use chemical mutagenesis as a forward-genetic strategy. More... »

PAGES

463-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri1109

DOI

http://dx.doi.org/10.1038/nri1109

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039641994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12776206


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