Organogenesis of lymphoid tissues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04

AUTHORS

Reina E Mebius

ABSTRACT

The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3-CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented. More... »

PAGES

292-303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri1054

DOI

http://dx.doi.org/10.1038/nri1054

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017023674

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12669020


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